From: Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Function | Regulators | Role in GBM | Related targets | References |
---|---|---|---|---|
Writer | METTL3 | Promote | ↑SOX2, SALL2, SSEA1, POU3F2, OLIG2 | [60] |
METTL3 | Inhibit | ↓EPHA3, ADAM19, KLF4 ↑CDKN2A, BRCA2, TP53I11 | [6] | |
METTL3 | Inhibit | ↓PI3K/Akt pathway | [61] | |
METTL3 | Promote | ↑NOTCH3, DLL3, HES1 | [63] | |
METTL3 | Promote | ↑VEGF | [65] | |
METTL3 | Promote | ↑MALAT1, NF-κB | [66] | |
METTL3 | Promote | ↑SRSF | [66] | |
METTL14 | Inhibit | ↓EPHA3, ADAM19, KLF4 ↑CDKN2A, BRCA2, TP53I11 | [6] | |
METTL14 | Promote | ↓ASS1 | [69] | |
WTAP | Promote | ↑EGFR | [71] | |
WTAP | Promote | ↑AKT, CCL2, CCL3, MMP3, LOXL1, THBS1, HAS1 | [57] | |
Eraser | ALKBH5 | Promote | ↑Foxm1 | [47] |
ALKBH5 | Promote | ↑G6PD, PPP | [82] | |
ALKBH5 | Promote | ↑Rad51, XRCC2, BRCA2, EXO1, BRIP1 | [84] | |
FTO | Promote | ↑MYC | [94] | |
Reader | YTHDF1 | Promote | NA | Â |
YTHDF2 | Promote | ↑MYC, IGFBP3 | [98] | |
YTHDF2 | Promote | ↓LXRα, HIVEP2 | [99] | |
YTHDF2 | Promote | ↓UBXN1 | [100] | |
YTHDF2 | Promote | ↓ASS1 | [69] | |
IGF2BP1 | Promote | ↑MAPK | [115] | |
IGF2BP2 | Promote | ↑let-7miRNA | [105] | |
IGF2BP2 | Promote | ↑PI3K/Akt | [107] | |
IGF2BP2 | Promote | ↑DANCR | [110] | |
IGF2BP3 | Promote | ↑PI3K/MAPK | [108] | |
IGF2BP3 | Promote | ↑p65 | [112] | |
IGF2BP3 | Promote | ↓E-cadherin | [111] | |
IGF2BP3 | Promote | ↑N-cadherin, vimentin, snail, slug and MMP9 | [111] | |
hnRNPA2B1 | Promote | ↑AKT, STAT3 pathway | [120] |