Fig. 8
From: Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis
CircPan3 inhibits cardiac hypertrophy in vivo. A CircPan3 AAV rescues ISO-induced downregulation of circPan3 in cardiac hypertrophy. The level of circPan3 in mouse hearts was analyzed by qPCR. **P < 0.01, n = 6. B–H CircPan3 alleviates cardiac hypertrophy. B Heart weight/body weight ratio of mice. **P < 0.01, n = 6. C Representative images of mouse whole hearts. D H&E staining of the heart sections (bar = 20 μm). E WGA staining of the heart sections (bar = 25 μm). F–H The expression level of ANP, BNP and β-MHC in mouse hearts was analyzed by qPCR. *P < 0.01. n = 6. I–M CircPan3 rescues impaired heart function. I Echocardiography of the mouse hearts. J EF, K FS, L LVIDs and M LVIDd were detected. *P < 0.01. n = 6. N The expression level of miR-320-3p in mouse hearts was analyzed by qPCR. n = 6. O The expression level of HSP20 in mouse hypertrophic cardiac tissue was analyzed by immunoblotting