Fig. 2

Volcano plot of kdAGC1 samples versus control (a). The X axis represents the magnitude of the change in expression levels, while the Y axis represents the significance of the change. Significance threshold was set to p adjusted < 0.05. Points in red are genes that are both significant and show |log₂FC| > 1, while blue points indicate genes that are significant and have |log₂FC| < 1. Points in gray represent genes that do not pass both thresholds. Enrichment score values (“combined score”) and significance levels for the top ten scoring Gene Ontology pathways obtained from gene set enrichment analysis (GSEA) (b). Scaled TPM values heatmap of a panel of genes that resulted as significant form differential gene expression analysis, for which log₂FC and p adjusted values are reported on the right of the heatmap (c)