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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway

Fig. 7

VBIT-12 mimicked the antiapoptotic effect of G6PD. A The molecular mechanism by which VBIT-12 inhibits VDAC1 oligomerization and apoptosis resistance. B TUNEL analysis was used to analyze cell apoptosis, and the TUNEL-positive cell ratio was quantified in 5 microscopic fields of view in each experiment. Scale bar = 100 µm. C The viability of VSMCs was assessed by a CCK8 assay. n = 7. D Cell proliferation was measured by a cell counting assay. n = 6. Ad-Null and DMSO were used as negative controls. Statistical significance was determined using two-tailed Student’s t tests (B) and two-way ANOVA (C, D); *P < 0.05; ***P < 0.001; ns, no significant difference

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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