Table 1 Summary of major ROS generators in hematopoietic cells
From: Role of reactive oxygen species in myelodysplastic syndromes
Name | Location | Product | Tissue distribution |
|---|---|---|---|
Mt ETC | Mitochondria | O ⋅−2 | Ubiquitous |
NOX1 | PM | O ⋅−2 | Colon epithelial cells, vascular smooth muscle, endosome |
NOX2 (gp91phox) | PM, ER, ES | O ⋅−2 | Phagocytes, lymphocytes, neurons |
NOX3 | PM | O ⋅−2 | Inner ear, fetal kidney, spleen |
NOX4 | ER, PM, nucleus | H2O2 | Kidney, endosome, vascular endothelial cells, vascular smooth muscle |
NOX5 | ER | O ⋅−2 | Spleen, testis, vascular smooth muscle |
DUOX1 | PM | H2O2 | Thyroid, lung, prostate, testis, salivary glands, pancreas |
DUOX2 | PM | H2O2 | Thyroid, intestinal tract |
XOR | Cyto, ExC | O ⋅−2 | Liver, intestine, mammal gland |
MPO | PM | HOCl | Bone marrow, phagocyte |
CYP3A4 | ER | O ⋅−2 /H2O2 | Liver, small intestine, duodenum |
CYP2D6 | ER | O ⋅−2 /H2O2 | Liver, small intestine |
CYP2E1 | ER, M | O ⋅−2 /H2O2 | Liver |
CYP4A11 | ER | O ⋅−2 /H2O2 | Kidney, liver |