The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Lei, Yuhang; Gan, Mailin; Qiu, Yanhao; Chen, Qiuyang; Wang, Xingyu; Liao, Tianci; Zhao, Mengying; Chen, Lei; Zhang, Shunhua; Zhao, Ye; Niu, Lili; Wang, Yan; Zhu, Li; Shen, Linyuan

doi:10.1186/s11658-024-00572-y

Table 3 Summary of conflicting studies regarding changes in mitochondrial dynamics, mitophagy, and other mitochondrial functions across different muscle atrophy models

From: The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Models	Mitochondrial function	Result	References
DMD gene-induced skeletal muscle atrophy	Mitophagy	↓	[140,141,142]
DMD gene-induced skeletal muscle atrophy	Mitochondrial ROS	↑	[143]
DMD gene-induced skeletal muscle atrophy	Mitochondrial respiration	↓	[144]
Denervation-induced skeletal muscle atrophy	Mitochondrial dynamics	Fusion↑ Fission↓	[145,146,147]
Denervation-induced skeletal muscle atrophy	Mitochondrial dynamics	Fission↑	[63]
Denervation-induced skeletal muscle atrophy	Mitophagy	↑	[148,149,150]
Denervation-induced skeletal muscle atrophy	Mitophagy	First ↑ Then ↓	[151]
Denervation-induced skeletal muscle atrophy	Mitochondrial ROS	↑	[151]
Denervation-induced skeletal muscle atrophy	Mitochondrial respiration	↓	[152]
Aging-related skeletal muscle atrophy	Mitochondrial dynamics	Fusion↑ Fission↓	[153, 154]
Aging-related skeletal muscle atrophy	Mitochondrial dynamics	Fission↑ Fusion↓	[155]
Aging-related skeletal muscle atrophy	Mitochondrial dynamics	Fusion↑ Fission↑	[80, 156]
Aging-related skeletal muscle atrophy	Mitochondrial dynamics	Fusion↓ Fission↓	[27, 35, 48, 56, 157]
Aging-related skeletal muscle atrophy	Mitochondrial dynamics	Unchanged	[131, 132, 158]
Aging-related skeletal muscle atrophy	Mitophagy	↑	[27, 80, 91]
Aging-related skeletal muscle atrophy	Mitophagy	↓	[134, 135, 159]
Aging-related skeletal muscle atrophy	Mitochondrial ROS	↑	[160]
Aging-related skeletal muscle atrophy	Mitochondrial ROS	Unchanged	[161]
Aging-related skeletal muscle atrophy	Mitochondrial respiration	Unchanged	[158]
Starvation-induced skeletal muscle atrophy	Mitochondrial dynamics	Fusion↓ Fission↓	[162, 163]
Starvation-induced skeletal muscle atrophy	Mitophagy	↑	[164]
Disuse-induced skeletal muscle atrophy	Mitochondrial dynamics	Fission↓ Fusion NS	[165]
Disuse-induced skeletal muscle atrophy	Mitochondrial dynamics	Unchanged	[166, 167]
Disuse-induced skeletal muscle atrophy	Mitophagy	↑	[168,169,170]
Disuse-induced skeletal muscle atrophy	Mitophagy	NS	[165, 166, 171]
Disuse-induced skeletal muscle atrophy	Mitochondrial respiration	NS	[172]
Disuse-induced skeletal muscle atrophy	Mitochondrial respiration	↓	[173]
Disuse-induced skeletal muscle atrophy	Mitochondrial ROS	↑	[173]
Cancer cachexia-induced skeletal muscle atrophy	Mitochondrial dynamics	Fusion↓ Fission↓	[163]

↑ Indicates increase, ↓ indicates decrease, and NS indicates no significant change.

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ISSN: 1689-1392

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