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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Fig. 1

cGAS–STING signaling activation accompanied by increased alveolar macrophage pyroptosis. A Flow chart for constructing the animal model of SAP (n = 6 per group). B Hematoxylin and eosin staining was used to observe the pancreatic and lung injury. C Injury score of pancreas and lungs. D The wet/dry weight ratio of the lungs. E Serum amylase level. F Serum IL-6 level. G WB of NLRP3, ASC, cGAS, and STING. H Flow cytometry was used to detect the pyroptosis of alveolar macrophages. I Pyroptosis rate of alveolar macrophages. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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