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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Fig. 7

Inhibition of IRF7 or IRF3 can alleviate lung injury and macrophage pyroptosis. A–C We induced SAP in wild-type mice after tail vein injection of si-IRF7 (n = 6 per group). HE staining and IHC of IRF7 in lung tissue (A). Score of lung injury and IHC (B). The levels of IL-1β, IL-6 and TNF-α in serum (C). D–F We induced SAP in wild-type mice after tail vein injection of si-IRF3 (n = 6 per group). HE staining and IHC of IRF3 in lung tissue (D). Score of lung injury and IHC (E). The levels of IL-1β, IL-6 and TNF-α in serum (F). G Flow cytometry was used to visualize pyroptosis of alveolar macrophages

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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