Fig. 1
From: miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
CVB3 induced VMC in mice. The male BALB/c mice were treated with 1 × 104 TCID50 CVB3 and then sacrificed on day 7 p.i. A A schematic diagram of the viral myocarditis modeling process induced by CVB3. B The body weight change of mice after CVB3 infection. C The survival rate of mice following CVB3 infection. D The appearance of mice on day 7 p.i. E M-mode images of heart and F The cardiac function was evaluated using echocardiography. G Heart appearance of mice on day 7 post CVB3 infection. H H&E staining of the heart tissue sections; the magnifications were 1.25 × , 10 × , 40 × , respectively, and the scale bar was 100 μm. I Quantification of inflammatory areas based on the images shown in H. N = 3, *p < 0.05, **p < 0.01, and ****p < 0.0001