Fig. 8
From: miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
Schematic representation of CVB3-induced miR-29b-3p-mediated pyroptosis in cardiomyocytes. Infection with CVB3 leads to an upregulation in the expression of cellular miR-29b-3p, which subsequently downregulates the expression of DNMT3A by binding to the 3′-UTR of DNMT3A. This reduction in DNMT3A levels activates the NLRP3 inflammasome, resulting in the cleavage of pro-caspase-1 into its active form. The activated cleaved caspase-1 then cleaves GSDMD, generating N-terminal fragments that form pores in the cell membrane and trigger pyroptosis. Additionally, cleaved caspase-1 also activates pro-IL-1β and pro-IL-18, promoting their maturation and release. This process exacerbates the inflammatory damage to myocardial cells, leading to myocardial damage and a decline in cardiac function