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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer

Fig. 1

Inhibition of proliferation, migration, and invasion of NSCLC cell lines by (+)-ABX. A Chemical structure of (+)-ABX. B Determination of IC50 values using CCK-8 assay. C Morphological changes in cells treated with various concentrations of (+)-ABX for 24 h. D Colony formation of NSCLC cells after treatment with different concentrations of (+)-ABX. Colony-forming ability was quantified by counting colonies per well. E Measurement of wound healing in NSCLC cells after (+)-ABX treatment. F Assessment of transwell migration and invasion of NSCLC cells after (+)-ABX treatment. G Quantitative analysis of wound healing, transwell migration, and invasion assays. The bar graphs represent mean ± SD of at least three independent experiments; *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the control group

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