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Cellular & Molecular Biology Letters

Open Access

The specific T-cell response to antigenic peptides is influenced by bystander peptides

  • Izabela Nowak1,
  • Elżbieta Pajtasz-Piasecka2,
  • Bartosz Chmielowski3,
  • Leszek Ignatowicz3 and
  • Piotr Kuśnierczyk1, 4Email author
Cellular & Molecular Biology LettersAn International Journal200611:7

Received: 13 September 2005

Accepted: 15 December 2005

Published: 01 March 2006


T lymphocytes recognize antigens in the form of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface. Only a small proportion of MHC class I and class II molecules are loaded with foreign antigenic peptides; the vast majority are loaded with thousands of different self peptides. It was suggested that MHC molecules presenting self peptides may serve either to decrease (antagonistic effect) or increase (synergistic effect) the T cell response to a specific antigen. Here, we present our finding that transfected mouse fibroblasts presenting a single antigenic peptide covalently bound to a class II MHC molecule stimulated specific mouse T cell hybridoma cells to an interleukin-2 response less efficiently than fibroblasts presenting a similar amount of antigenic peptide in the presence of class II molecules loaded with heterogenous bystander peptides.

Key Words

Bystander peptideT cell responseTransfectantsMouse model