Germain, R.N. and Štefanová, I. The dynamics of T cell receptor signalling: Complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol.
17 (1999) 467–522.
Article
PubMed
CAS
Google Scholar
Marrack, P., Ignatowicz, L., Kappler, J.W., Boymel, J. and Freed, J.H. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med.
178 (1993) 2173–2183.
Article
PubMed
CAS
Google Scholar
Derbinski, J., Schulte, A., Kyewski, B. and Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol.
2 (2001) 1032–1039.
Article
PubMed
CAS
Google Scholar
Wülfing, C., Sumen, C., Sjaastad, M.D., Wu, L.C., Dustin, M.L. and Davis, M.M. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat. Immunol.
3 (2002) 42–47.
Article
PubMed
Google Scholar
Sporri, R. and Reis e Sousa, C. Self peptide/MHC class I complexes have a negligible effect on the response of some CD8+ T cells to foreign antigen. Eur. J. Immunol.
32 (2002) 3161–3170.
Article
PubMed
CAS
Google Scholar
Ignatowicz, L., Winslow, G., Bill, J., Kappler, J. and Marrack, P. Cell surface expression of class II MHC proteins bound by a single peptide. J. Immunol.
154 (1995) 3852–3862.
PubMed
CAS
Google Scholar
Ignatowicz, L., Rees, W., Pacholczyk, R., Ignatowicz, H., Kushnir, E., Kappler, J. and Marrack, P. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity
7 (1997) 179–186.
Article
PubMed
CAS
Google Scholar
Gillis, S. and Smith, K.A. Long term culture of tumour-specific cytotoxic T cells. Nature
268 (1977) 154–156.
Article
PubMed
CAS
Google Scholar
Watson, J. Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J. Exp. Med.
150 (1979) 1510–1519.
Article
PubMed
CAS
Google Scholar
Pajtasz-Piasecka, E., Kuśnierczyk, H., Salwa, J., Konarski L. and Radzikowski, C. Growth inhibition of transplantable tumors in mice by mIL-2-secreting murine plasmocytoma cells used alone or in combination with a cytostatic agent. Arch. Immunol. Ther. Exp.
43 (1995) 281–292.
CAS
Google Scholar
Janeway, C.A., Conrad, P., Lerner, E., Babich, J., Wettstein, P. and Murphy, D. Monoclonal antibodies specific for Ia antigens as targets of immunoregulatory T cells. J. Immunol.
132 (1984) 662–669.
PubMed
Google Scholar
Murphy, D., Lo, D., Rath, S., Brinster, R., Flavel, R., Slanetz, A. and Janeway, C. A novel MHC class II epitope expressed in thymic medulla but not cortex. Nature
338 (1989) 765–768.
Article
PubMed
CAS
Google Scholar
Ignatowicz, L., Kappler, J. and Marrack, P. The repertoire of T cells selected by a single MHC/peptide ligand. Cell
84 (1996) 521–529.
Article
PubMed
CAS
Google Scholar
Davis, S.J. and van der Merwe, P.A. TCR triggering: co-receptor-dependent or-independent? Trends Immunol.
24 (2003) 624–626.
Article
PubMed
CAS
Google Scholar
Greenwald, R.J., Latchman, Y. and Sharpe, A.H. Negative co-receptors on lymphocytes. Curr. Opin. Immunol.
14 (2002) 391–396.
Article
PubMed
CAS
Google Scholar
Iezzi, G., Karjalainen, K. and Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity
8 (1998) 89–95.
Article
PubMed
CAS
Google Scholar
Holzer, U., Kwok, W.W., Nepom, G.T. and Buckner, J.H. Differential antigen sensitivity and costimulatory requirements in human Th1 and Th2 antigen-specific CD4+ cells with similar TCR avidity. J. Immunol.
170 (2003) 1218–1223.
PubMed
CAS
Google Scholar
Kraj, P., Pacholczyk, R., Ignatowicz, H., Kisielow, P., Jensen, P. and Ignatowicz, L. Positive selection of CD4+ T cells is induced in vivo by agonist and inhibited by antagonist peptides. J. Exp. Med.
194 (2001) 407–416.
Article
PubMed
CAS
Google Scholar
Viret, C., He, X. and Janeway, C.A. Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide. Proc. Natl. Acad. Sci. U.S.A.
98 (2001) 9243–9248.
Article
PubMed
CAS
Google Scholar
Bouneaud, C., Kourilsky, P. and Bousso, P. Impact of negative selection on the T cell repertoire reactive to a self-peptide; a large fraction of T cell clones escapes clonal deletion. Immunity
13 (2000) 829–840.
Article
PubMed
CAS
Google Scholar
Yan, J. and Mamula, M.J. Autoreactive T cells revealed in the normal reperoire: escape from negative selection and peripheral tolerance. J. Immunol.
168 (2002) 3188–3194.
PubMed
CAS
Google Scholar
Cohen, I.R., Hershberg, U. and Solomon, S. Antigen-receptor degeneracy and immunological paradigms. Mol. Immunol.
40 (2004) 993–996.
Article
PubMed
CAS
Google Scholar
Ford, M.L. and Evavold, B.D. Degenerate recognition of T cell epitopes: impact on T cell receptor reserve and stability of peptide: MHC complexes. Mol. Immunol.
40 (2004) 1019–1025.
Article
PubMed
CAS
Google Scholar
Sercarz, E.E. and Maverakis, E. Recognition and function in a degenerate immune system. Mol. Immunol.
40 (2004) 1003–1008.
Article
PubMed
CAS
Google Scholar
Wilson, D.B., Wilson, D.H., Schroder, K., Pinilla, C., Blondelle, S., Houghten, R.A. and Garcia, K.C. Specificity and degeneracy of T cells. Mol. Immunol.
40 (2004) 1047–1055.
Article
PubMed
CAS
Google Scholar
Thibault, G. and Bardos, P. Compared TCR and CD3ε expression on αβ and γδ T cells. J. Immunol.
154 (1995) 3814–3820.
PubMed
CAS
Google Scholar
Zapata, D.A., Schamel, W.W.A., Torres, P.S., Alarcón, B., Rossi, N.E., Navarro, M.N., Toribio, M.L., and Regueiro, J.R. Biochemical differences in the alphabeta T cell receptor. CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes. J. Biol. Chem.
279 (2004) 24485–24492.
Article
PubMed
CAS
Google Scholar
Chmielowski, B., Pacholczyk, R., Kraj, P., Kisielow, P. and Ignatowicz, L. Presentation of antagonist peptides to naive CD4+ T cells abrogates spatial reorganization of class II MHC peptide complexes on the surface of dendritic cells. Proc. Natl. Acad. Sci. U.S.A.
99 (2002) 15012–15017.
Article
PubMed
CAS
Google Scholar
Bakker, T.R. and van der Merve, P.A. Self-help in T cell recognition? Nat. Immunol.
3 (2002) 11–12.
Article
PubMed
CAS
Google Scholar
Štefanová, I., Dorfman, J.R., Tsukamoto, M. and Germain R.N. On the role of self-recognition in T cell responses to foreign antigen. Immunol. Rev.
191 (2003) 97–106.
Article
PubMed
Google Scholar
Štefanova, I., Dorfman, J.R. and Germain R.N. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature
420 (2002) 429–433.
Article
PubMed
Google Scholar
Choi, J. and Craft, J. Activation of naive CD4+ T cells in vivo by a self peptide mimic: mechanism of tolerance maintenance and preservation of immunity. J. Immunol.
172 (2004) 7399–7406.
PubMed
CAS
Google Scholar