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Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein

Cellular & Molecular Biology Letters volume 11, pages 102–108 (2006)Cite this article

Abstract

The human NR4A1 orphan receptor is a member of the TR3 steroid receptor superfamily, which binds DNA at the NBRE and NurRE responsive elements. The TR3 receptors are involved in the regulation of differentiation, proliferation and apoptosis. We report that NR4A1 interacts with human papillomavirus type 16 (HPV16) E2 protein — a key papillomavirus regulatory factor. This interaction might be involved in the transcription regulation of the HPV16 genes and the regulation of infected cell homeostasis.

Abbreviations

HPV:

human papillomavirus

EGFP:

enhanced green fluorescent protein

HA:

hemagglutinin

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Authors and Affiliations

  1. Department of Biotechnology and Food Microbiology, August Cieszkowski University of Agriculture, Wojska Polskiego 48, 60-627, Poznań, Poland

    Agnieszka K. Olejnik-Schmidt & Marcin T. Schmidt

  2. Department of Molecular Virology, Adam Mickiewicz University, Międzychodzka 5, 60-371, Poznań, Poland

    Agnieszka K. Olejnik-Schmidt & Anna Goździcka-Józefiak

Authors
  1. Agnieszka K. Olejnik-Schmidt
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  2. Marcin T. Schmidt
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  3. Anna Goździcka-Józefiak
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Correspondence to Marcin T. Schmidt.

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Olejnik-Schmidt, A.K., Schmidt, M.T. & Goździcka-Józefiak, A. Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein. Cell. Mol. Biol. Lett. 11, 102–108 (2006). https://doi.org/10.2478/s11658-006-0010-x

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  • DOI: https://doi.org/10.2478/s11658-006-0010-x

Key words

  • NR4A1
  • Nur77
  • E2
  • HPV16
  • Two-hybrid system
  • Nuclear localization
  • Colocalization studies

Cellular & Molecular Biology Letters

ISSN: 1689-1392

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