Open Access

Degradation and beyond: Control of androgen receptor activity by the proteasome system

Cellular & Molecular Biology LettersAn International Journal200611:109

https://doi.org/10.2478/s11658-006-0011-9

Received: 6 December 2005

Accepted: 31 January 2006

Published: 01 March 2006

Abstract

The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors which mediates the action of androgens in the development of urogenital structures. AR expression is regulated post-translationally by the ubiquitin/proteasome system. This regulation involves more complex mechanisms than typical degradation. The ubiquitin/proteasome system may regulate AR via mechanisms that do not engage in receptor turnover. Given the critical role of AR in sexual development, this complex regulation is especially important. Deregulation of AR signalling may be a causal factor in prostate cancer development. AR is the main target in prostate cancer therapies. Due to the critical role of the ubiquitin/proteasome system in AR regulation, current research suggests that targeting AR degradation is a promising approach.

Key words

AR Degradation Prostate cancer Proteasome Transcription Ubiquitin

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