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Cellular & Molecular Biology Letters

Open Access

The breakdown of bilayer lipid membranes by dendrimers

  • Dzmitry Shcharbin1,
  • Alexander Drapeza2,
  • Valeri Loban2,
  • Alexej Lisichenok2 and
  • Maria Bryszewska1Email author
Cellular & Molecular Biology LettersAn International Journal200611:18

Received: 3 January 2006

Accepted: 16 March 2006

Published: 01 June 2006


The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.

Key words

PAMAM dendrimerPlanar bilayer lipid membraneConductivityVoltammetry