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The breakdown of bilayer lipid membranes by dendrimers


The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.


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Correspondence to Maria Bryszewska.

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Shcharbin, D., Drapeza, A., Loban, V. et al. The breakdown of bilayer lipid membranes by dendrimers. Cell. Mol. Biol. Lett. 11, 242–248 (2006).

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Key words

  • PAMAM dendrimer
  • Planar bilayer lipid membrane
  • Conductivity
  • Voltammetry