Skip to main content


  • Short Communication
  • Open Access

The breakdown of bilayer lipid membranes by dendrimers

  • 1,
  • 2,
  • 2,
  • 2 and
  • 1Email author
Cellular & Molecular Biology LettersAn International Journal200611:18

  • Received: 3 January 2006
  • Accepted: 16 March 2006
  • Published:


The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.

Key words

  • PAMAM dendrimer
  • Planar bilayer lipid membrane
  • Conductivity
  • Voltammetry