- Published:
Endoplasmic reticulum stress and apoptosis
Cellular & Molecular Biology Letters volume 11, pages 488–505 (2006)
Abstract
Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.
Abbreviations
- ATF6:
-
activating transcription factor 6
- BAP31:
-
B-cell receptorassociated protein 31
- BiP:
-
luminal binding protein
- C/EBP:
-
CCAAT/enhancerbinding proteins
- eIF-2α:
-
eukaryotic translation initiation factor
- EOR:
-
ER overloaded response
- ER:
-
endoplasmic reticulum
- GADD 153:
-
growth arrest and DNA damage
- GCN2:
-
general control of amino acid biosynthesis kinase
- GRPs:
-
glucose-regulated protein family
- GSK3β:
-
glycogen synthetase kinase-3β
- HRI:
-
hemin-regulated inhibitor of protein synthesis
- IP3:
-
inositol 1,4,5-trisphosphate
- IRE1:
-
inositolrequiring gene-1
- IRF-1:
-
interferon regulatory factor 1
- MEFs:
-
mouse embryonic fibroblasts
- NF-κB:
-
nuclear factor-κB
- PDI:
-
protein disulphide isomerase
- PERK:
-
PKR-like ER kinase
- PKR:
-
interferon-inducible
- dsRNA:
-
activated protein kinase
- PS1, 2:
-
presenilin-1,-2
- SREBPs:
-
sterol-regulatory element-binding proteins
- SRP 72:
-
72 kDa component of SRP (signal recognition particle)
- UPR:
-
unfolded protein response
- XBP1:
-
X-Box protein-1
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Faitova, J., Krekac, D., Hrstka, R. et al. Endoplasmic reticulum stress and apoptosis. Cell Mol Biol Lett 11, 488–505 (2006). https://doi.org/10.2478/s11658-006-0040-4
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DOI: https://doi.org/10.2478/s11658-006-0040-4