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Endoplasmic reticulum stress and apoptosis


Cell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death processes. In cells, the ER functions as the organelle where proteins mature, and as such, is very responsive to extracellular-intracellular changes of environment. This short overview focuses on the known pathways of programmed cell death triggering from or involving the ER.



activating transcription factor 6


B-cell receptorassociated protein 31


luminal binding protein


CCAAT/enhancerbinding proteins


eukaryotic translation initiation factor


ER overloaded response


endoplasmic reticulum

GADD 153:

growth arrest and DNA damage


general control of amino acid biosynthesis kinase


glucose-regulated protein family


glycogen synthetase kinase-3β


hemin-regulated inhibitor of protein synthesis


inositol 1,4,5-trisphosphate


inositolrequiring gene-1


interferon regulatory factor 1


mouse embryonic fibroblasts


nuclear factor-κB


protein disulphide isomerase


PKR-like ER kinase




activated protein kinase

PS1, 2:



sterol-regulatory element-binding proteins

SRP 72:

72 kDa component of SRP (signal recognition particle)


unfolded protein response


X-Box protein-1


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Correspondence to Borivoj Vojtesek.

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Faitova, J., Krekac, D., Hrstka, R. et al. Endoplasmic reticulum stress and apoptosis. Cell Mol Biol Lett 11, 488–505 (2006).

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Key words

  • Endoplasmic reticulum
  • Apoptosis
  • p53
  • Scotin