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N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients


The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.



American College of Chest Physicians/Society of Critical Care Medicine

APACHE II score:

acute physiological and chronic health evaluation ii score


brain natriuretic peptide


C-reactive protein


N-terminal brain natriuretic propeptide




systemic inflammatory response syndrome

SOFA score:

sepsis-related organ failure assessment score


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Correspondence to Maciej Banach.

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Piechota, M., Banach, M., Irzmański, R. et al. N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients. Cell Mol Biol Lett 12, 162–175 (2007).

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Key words

  • N-terminal brain natriuretic propeptide
  • Procalcitonin
  • C-reactive protein
  • Sepsis
  • Severe sepsis