Open Access

Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine

  • Józefa Węsierska-Gądek1Email author,
  • Tanja Schreiner1,
  • Margarita Maurer1,
  • Astrid Waringer1 and
  • Carmen Ranftler1
Cellular & Molecular Biology LettersAn International Journal200712:2

https://doi.org/10.2478/s11658-007-0002-5

Received: 21 August 2006

Accepted: 26 October 2006

Published: 19 January 2007

Abstract

Estrogens play an important role in the growth and terminal differentiation of the mammary gland. Prolonged exposure to estrogens seems to predispose women to breast cancer. It recently became evident that not only the intrinsic hormonal status but also external factors such as the occurrence of pharmaceuticals and chemicals with hormone activity in the environment may put women at greater risk of developing breast cancer. We focused on the interference of endocrine disruptors in breast cancer therapy. We observed that phenol red added to the culture medium strongly promoted the cell proliferation and cell cycle progression of human cells expressing the estrogen receptor, and affected their susceptibility to chemotherapy.

Key words

Endocrine disruptersApoptosisCell cycle arrestCyclin-dependent inhibitors

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