Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine
Cellular & Molecular Biology Letters volume 12, pages 280–293 (2007)
Estrogens play an important role in the growth and terminal differentiation of the mammary gland. Prolonged exposure to estrogens seems to predispose women to breast cancer. It recently became evident that not only the intrinsic hormonal status but also external factors such as the occurrence of pharmaceuticals and chemicals with hormone activity in the environment may put women at greater risk of developing breast cancer. We focused on the interference of endocrine disruptors in breast cancer therapy. We observed that phenol red added to the culture medium strongly promoted the cell proliferation and cell cycle progression of human cells expressing the estrogen receptor, and affected their susceptibility to chemotherapy.
apoptosis inducing factor
endocrine disrupting compounds
foetal calf serum
whole cell lysates
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Węsierska-Gądek, J., Schreiner, T., Maurer, M. et al. Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine. Cell Mol Biol Lett 12, 280–293 (2007). https://doi.org/10.2478/s11658-007-0002-5
- Endocrine disrupters
- Cell cycle arrest
- Cyclin-dependent inhibitors