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  • Open Access

High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

  • 1Email author,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2 and
  • 1
Cellular & Molecular Biology LettersAn International Journal200712:9

  • Received: 29 August 2006
  • Accepted: 28 November 2006
  • Published:


In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.


  • IL-8
  • E-cadherin
  • Prostate cancer cell line