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High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Cellular & Molecular Biology Letters volume 12, pages 370–377 (2007)Cite this article

Abstract

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

Abbreviations

DHT:

5α-dihydrotestosterone

IL-8:

interleukin-8

PSA:

prostate specific antigen

STAG1:

solid tumor associated gene 1

STR:

short tandem repeat

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Authors and Affiliations

  1. Department of Pathological Oncology, Institute of Molecular and Experimental Medicine, Faculty of Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Yoshifumi S. Hirokawa, Akimitsu Takagi, Katsunori Uchida, Yuji Kozuka, Misao Yoneda & Taizo Shiraishi

  2. Laboratory for Medical Engineering, Division of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama, Japan

    Masatoshi Watanabe

Authors
  1. Yoshifumi S. Hirokawa
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  2. Akimitsu Takagi
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  3. Katsunori Uchida
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  4. Yuji Kozuka
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  5. Misao Yoneda
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  6. Masatoshi Watanabe
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  7. Taizo Shiraishi
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Correspondence to Yoshifumi S. Hirokawa.

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Hirokawa, Y.S., Takagi, A., Uchida, K. et al. High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. Cell Mol Biol Lett 12, 370–377 (2007). https://doi.org/10.2478/s11658-007-0009-y

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  • DOI: https://doi.org/10.2478/s11658-007-0009-y

Keywords

Cellular & Molecular Biology Letters

ISSN: 1689-1392

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