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High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

  • Yoshifumi S. Hirokawa1Email author,
  • Akimitsu Takagi1,
  • Katsunori Uchida1,
  • Yuji Kozuka1,
  • Misao Yoneda1,
  • Masatoshi Watanabe2 and
  • Taizo Shiraishi1
Cellular & Molecular Biology LettersAn International Journal200712:9

Received: 29 August 2006

Accepted: 28 November 2006

Published: 23 February 2007


In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.


STAG1/PMEPA1IL-8E-cadherinProstate cancer cell line