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High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

Abstract

In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

Abbreviations

DHT:

5α-dihydrotestosterone

IL-8:

interleukin-8

PSA:

prostate specific antigen

STAG1:

solid tumor associated gene 1

STR:

short tandem repeat

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Correspondence to Yoshifumi S. Hirokawa.

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Hirokawa, Y.S., Takagi, A., Uchida, K. et al. High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. Cell Mol Biol Lett 12, 370–377 (2007). https://doi.org/10.2478/s11658-007-0009-y

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  • DOI: https://doi.org/10.2478/s11658-007-0009-y

Keywords

  • STAG1/PMEPA1
  • IL-8
  • E-cadherin
  • Prostate cancer cell line