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High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone


In this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.







prostate specific antigen


solid tumor associated gene 1


short tandem repeat


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Correspondence to Yoshifumi S. Hirokawa.

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Hirokawa, Y.S., Takagi, A., Uchida, K. et al. High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. Cell Mol Biol Lett 12, 370–377 (2007).

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  • IL-8
  • E-cadherin
  • Prostate cancer cell line