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  • Mini review
  • Open Access

The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research

Cellular & Molecular Biology LettersAn International Journal200813:8

https://doi.org/10.2478/s11658-008-0008-7

  • Received: 1 June 2007
  • Accepted: 10 December 2007
  • Published:

Abstract

The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-κB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.

Keywords

  • E3 ubiquitin ligases
  • Proteasome
  • Inhibitors
  • Modulators
  • Therapeutic potential
  • Cancer
  • Stroke
  • Cardiovascular diseases

Notes

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