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Cellular & Molecular Biology Letters

Open Access

The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research

Cellular & Molecular Biology LettersAn International Journal200813:8

Received: 1 June 2007

Accepted: 10 December 2007

Published: 29 February 2008


The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-κB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.


E3 ubiquitin ligasesProteasomeInhibitorsModulatorsTherapeutic potentialCancerStrokeCardiovascular diseases