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  • Research Article
  • Open Access

The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

  • 1Email author,
  • 2,
  • 2 and
  • 1
Cellular & Molecular Biology LettersAn International Journal200813:13

https://doi.org/10.2478/s11658-008-0013-x

  • Received: 25 October 2007
  • Accepted: 29 January 2008
  • Published:

Abstract

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.

Key words

  • Triterpene saponoside
  • Cytotoxicity
  • Lysimachia thyrsiflora L.
  • Melanoma
  • Fibroblasts

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