Open Access

On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel

Cellular & Molecular Biology LettersAn International Journal200813:526

Received: 1 October 2007

Accepted: 29 January 2008

Published: 10 May 2008


We describe a new factor in the recovery from inactivation in the ball and chain model. We propose a model in which the tension from the chain may help pull the ball away from its binding site, reducing the duration of the inactivation period. A corresponding model was built and analysed.

Key words

Ion channels Inactivation Recovery from inactivation Ball and chain model