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On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel


We describe a new factor in the recovery from inactivation in the ball and chain model. We propose a model in which the tension from the chain may help pull the ball away from its binding site, reducing the duration of the inactivation period. A corresponding model was built and analysed.



Boltzmann constant times environment temperature


right-hand side


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Correspondence to Przemysław Borys.

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Paper authored by participants of the international conference: International Workshop on Ionic Channels, Szczyrk, Poland, May 27 – June 01, 2007. Publication cost was covered by the organisers of this meeting.

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Borys, P., Grzywna, Z.J. On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel. Cell Mol Biol Lett 13, 526–534 (2008).

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Key words

  • Ion channels
  • Inactivation
  • Recovery from inactivation
  • Ball and chain model