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Cellular & Molecular Biology Letters

Open Access

Acheron, an novel LA antigen family member, binds to cask and forms a complex with id transcription factors

  • Haifeng Weng1, 2,
  • Chul Kim1,
  • Christos Valavanis3, 4,
  • Zhaohui Wang1 and
  • Lawrence M. Schwartz1, 3, 5Email author
Cellular & Molecular Biology LettersAn International Journal200814:46

Received: 9 July 2008

Accepted: 10 December 2008

Published: 18 December 2008

The Erratum to this article has been published in Cellular & Molecular Biology Letters 2009 14:5


Acheron, a Lupus antigen ortholog, was identified as a novel death-associated transcript from the intersegmental muscles of the mothManduca sexta. Acheron is phylogenetically-conserved and represents a new sub-family of Lupus antigen proteins. Acheron is expressed predominantly in neurons and muscle in vertebrates, and regulates several developmental events including myogenesis, neurogenesis and possibly metastasis. Using Acheron as bait, we performed a yeast two-hybrid screen with a mouse embryo cDNA library and identified CASK-C, a novel CASK/Lin-2 isoform, as an Acheron binding partner. Acheron and CASK-C bind via the C-terminus of Acheron and the CaMKII-like domain of CASK-C. Co-immunoprecipitation assays verify this interaction and demonstrate that Acheron also forms a complex with all members of the Id (inhibitor of differentiation) proteins. Taken together, these data suggest a mechanism by which Acheron may regulate development and pathology.

Key words

Programmed cell death Manduca sexta MuscleApoptosisLupus antigen protein