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Cellular & Molecular Biology Letters

Open Access

The prediction of novel multiple lipid-binding regions in protein translocation motor proteins: A possible general feature

Cellular & Molecular Biology LettersAn International Journal201016:36

Received: 27 June 2010

Accepted: 12 October 2010

Published: 19 October 2010


Protein translocation is an important cellular process. SecA is an essential protein component in the Sec system, as it contains the molecular motor that facilitates protein translocation. In this study, a bioinformatics approach was applied in the search for possible lipid-binding helix regions in protein translocation motor proteins. Novel lipid-binding regions in Escherichia coli SecA were identified. Remarkably, multiple lipid-binding sites were also identified in other motor proteins such as BiP, which is involved in ER protein translocation. The prokaryotic signal recognition particle receptor FtsY, though not a motor protein, is in many ways related to SecA, and was therefore included in this study. The results demonstrate a possible general feature for motor proteins involved in protein translocation.

Key words

Lipid-binding regionsMotor proteinsProtein-lipid interactionsProtein translocationSecA