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Stem cells from adipose tissue

Cellular & Molecular Biology Letters volume 16, pages 236–257 (2011)Cite this article

Abstract

This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.

Abbreviations

ASCs:

adipose-derived stem/stromal cells

BAT:

brown adipose tissue

BM-MSCs:

bone marrow mesenchymal stem cells

BMP:

bone morphogenetic protein

ES:

embryonic stem

HGF:

hepatocyte growth factor

HSCs:

hematopoietic stem cells

IGF:

insulin growth factor

Il:

interleukin

M-CSF:

macrophage colony stimulating factor

MSCs:

mesenchymal stem cells

Runx2:

runt-related transcription factor 2

SVF:

stromal-vascular cell fraction

TGF-β1:

transforming growth factor-β1

TNFα:

tumor necrosis factor α

WAT:

white adipose tissue

VEGF:

vascular endothelial growth factor

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  1. Department of Biophysics and Human Physiology, Medical University of Warsaw, Chalubinskiego 5, 02-004, Warsaw, Poland

    Malgorzata Witkowska-Zimny & Katarzyna Walenko

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  1. Malgorzata Witkowska-Zimny
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Correspondence to Malgorzata Witkowska-Zimny.

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Witkowska-Zimny, M., Walenko, K. Stem cells from adipose tissue. Cell Mol Biol Lett 16, 236–257 (2011). https://doi.org/10.2478/s11658-011-0005-0

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Cellular & Molecular Biology Letters

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