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Cellular & Molecular Biology Letters

Open Access

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Cellular & Molecular Biology LettersAn International Journal201116:16

Received: 14 April 2011

Accepted: 9 June 2011

Published: 18 July 2011


The ADAM (A Disintegrin and Metalloprotease) family of transmembrane proteins plays important roles in embryogenesis and tissue formation based on their multiple functional domains. In the present study, for the first time, the expression patterns of the premature and the active forms of six members of the ADAM proteins — ADAM9, ADAM10, ADAM12, ADAM17, ADAM22 and ADAM23 — in distinct parts of the developing chicken brain were investigated by quantitative Western blot analysis from embryonic incubation day (E) 10 to E20. The results show that the premature and the active forms of various ADAM proteins are spatiotemporally regulated in different parts of the brain during development, suggesting that the ADAMs play a very important role during embryonic development.

Key words

ADAMGene expressionProteinBrain developmentChicken