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Cellular & Molecular Biology Letters

Open Access

ERp57/GRP58: A protein with multiple functions

  • Carlo Turano1Email author,
  • Elisa Gaucci1,
  • Caterina Grillo1 and
  • Silvia Chichiarelli1
Cellular & Molecular Biology LettersAn International Journal201116:539

Received: 22 March 2011

Accepted: 3 August 2011

Published: 11 August 2011


The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.

Key words

Protein disulfide isomerasesCalcitriolSTAT3Cellular stressSignal transductionDNA repair