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ERp57/GRP58: A protein with multiple functions

Abstract

The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.

Abbreviations

1α,25-(OH)2D3 :

1α,25-dihydroxycholecalciferol and calcitriol

APE/Ref-1:

apurinic (apyrimidinic) endonuclease/redox-factor 1

CRP:

C-reactive protein

ER:

endoplasmic reticulum

ERAD:

endoplasmic reticulum associated protein degradation

mTORC:

mammalian target of rapamycin complex

PDI:

protein disulfide isomerase

PKC:

protein kinases C

PLA2 :

phospholipases A2

Plc:

peptide loading complex

PLC:

phospholipase C

PrPSC :

scrapie prion protein (misfolded prions)

STAT:

signal transducer and activator of transcription

STAT3:

signal transducer and activator of transcription 3

SV40 virus:

simian virus 40

VDR:

vitamin D receptor

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Correspondence to Carlo Turano.

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Turano, C., Gaucci, E., Grillo, C. et al. ERp57/GRP58: A protein with multiple functions. Cell Mol Biol Lett 16, 539 (2011). https://doi.org/10.2478/s11658-011-0022-z

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Key words

  • Protein disulfide isomerases
  • Calcitriol
  • STAT3
  • Cellular stress
  • Signal transduction
  • DNA repair