Open Access

Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

  • Hongyan Li1, 2,
  • Shaoming Tong1, 2,
  • Jiwei Liu3,
  • Li Han1,
  • Xuesong Yang1,
  • Hesheng Hou2,
  • Qiu Yan1 and
  • Xiao-Qi Wang4Email author
Cellular & Molecular Biology LettersAn International Journal201217:3

https://doi.org/10.2478/s11658-012-0003-x

Received: 15 June 2011

Accepted: 20 January 2012

Published: 27 January 2012

Abstract

Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.

Key words

FucosyltransferaseFUT4 promoterMethylationA431 cellsSCC12 cells

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