Autophagy favors Brucella melitensis survival in infected macrophages
© © Versita Warsaw and Springer-Verlag Wien 2012
Received: 20 July 2011
Accepted: 16 February 2012
Published: 24 February 2012
This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.