- Mini review
Regulation of angiogenesis by hypoxia: the role of microRNA
Cellular & Molecular Biology Letters volume 18, pages 47–57 (2013)
Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.
member six of the DEAD box protein family
extracellular signal-regulated kinases
v-ets erythroblastosis virus E26 oncogene homolog 1
factor inhibiting HIF-1
- hnRNP L:
heterogeneous nuclear ribonucleoprotein L
miRNA-induced silencing complex
signal transducer and activator of transcription 3
vascular endothelial growth factor
vascular endothelial growth factor receptor-2
gene encoding von Hippel-Lindau tumor suppressor protein
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Madanecki, P., Kapoor, N., Bebok, Z. et al. Regulation of angiogenesis by hypoxia: the role of microRNA. Cell Mol Biol Lett 18, 47–57 (2013). https://doi.org/10.2478/s11658-012-0037-0