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Regulation of angiogenesis by hypoxia: the role of microRNA

Abstract

Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.

Abbreviations

3′UTR:

3′-untranslated region

CUL2:

cullin 2

DDX6:

member six of the DEAD box protein family

DUSP2:

dual-specificity phosphatase-2

EFNA3:

ephrin-A3

ERK:

extracellular signal-regulated kinases

Ets-1:

v-ets erythroblastosis virus E26 oncogene homolog 1

FIH:

factor inhibiting HIF-1

HIF:

hypoxia-inducible factor

hnRNP L:

heterogeneous nuclear ribonucleoprotein L

HRE:

hypoxia-response element

miRNA:

microRNA

PHD2:

proline-hydroxylase-2

RISC:

miRNA-induced silencing complex

SIRi1:

sirtuin

STAT3:

signal transducer and activator of transcription 3

VEGF:

vascular endothelial growth factor

VEGFR2:

vascular endothelial growth factor receptor-2

VHL:

gene encoding von Hippel-Lindau tumor suppressor protein

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Correspondence to Rafal Bartoszewski.

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Madanecki, P., Kapoor, N., Bebok, Z. et al. Regulation of angiogenesis by hypoxia: the role of microRNA. Cell Mol Biol Lett 18, 47–57 (2013). https://doi.org/10.2478/s11658-012-0037-0

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  • DOI: https://doi.org/10.2478/s11658-012-0037-0

Key words

  • Angiogenesis
  • Hypoxia
  • microRNA
  • miRNA
  • HypoxamiR
  • HIF
  • VEGF