Open Access

Regulation of angiogenesis by hypoxia: the role of microRNA

  • Piotr Madanecki1,
  • Niren Kapoor2,
  • Zsuzsa Bebok3,
  • Renata Ochocka1,
  • James F. Collawn3 and
  • Rafal Bartoszewski1, 4Email author
Cellular & Molecular Biology LettersAn International Journal201218:37

https://doi.org/10.2478/s11658-012-0037-0

Received: 29 August 2012

Accepted: 24 October 2012

Published: 3 November 2012

Abstract

Understanding the cellular pathways that regulate angiogenesis during hypoxia is a necessary aspect in the development of novel treatments for cardiovascular disorders. Although the pathways of angiogenesis have been extensively studied, there is limited information on the role of miRNAs in this process. miRNAs or their antagomirs could be used in future therapeutic approaches to regulate hypoxia-induced angiogenesis, so it is critical to understand their role in governing angiogenesis during hypoxic conditions. Although hypoxia and ischemia change the expression profile of many miRNAs, a functional role for a limited number of so-called hypoxamiRs has been demonstrated in angiogenesis. Here, we discuss the best examples that illustrate the role of hypoxamiRs in angiogenesis.

Key words

Angiogenesis Hypoxia microRNA miRNA HypoxamiR HIF VEGF

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