Open Access

Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis

Cellular & Molecular Biology LettersAn International Journal201318:95

https://doi.org/10.2478/s11658-013-0095-y

Received: 27 March 2013

Accepted: 13 June 2013

Published: 20 June 2013

Abstract

Prostate cancer is one of the main cancers that affect men, especially older men. Though there has been considerable progress in understanding the progression of prostate cancer, the drivers of its development need to be studied more comprehensively. The emergence of resistant forms has also increased the clinical challenges involved in the treatment of prostate cancer. Recent evidence has suggested that inflammation might play an important role at various stages of cancer development. This review focuses on inflammasome research that is relevant to prostate cancer and indicates future avenues of study into its effective prevention and treatment through inflammasome regulation. With regard to prostate cancer, such research is still in its early stages. Further study is certainly necessary to gain a broader understanding of prostate cancer development and to create successful therapy solutions.

Key words

Inflammation Adaptor protein ASC Caspase-1 Prostate cancer IFI16 caspase-1 IL-1β IL-18 NLR

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