Open Access

Yeast ABC proteins involved in multidrug resistance

Cellular & Molecular Biology LettersAn International Journal201319:111

https://doi.org/10.2478/s11658-013-0111-2

Received: 14 August 2013

Accepted: 27 November 2013

Published: 2 December 2013

Abstract

Pleiotropic drug resistance is a complex phenomenon that involves many proteins that together create a network. One of the common mechanisms of multidrug resistance in eukaryotic cells is the active efflux of a broad range of xenobiotics through ATP-binding cassette (ABC) transporters. Saccharomyces cerevisiae is often used as a model to study such activity because of the functional and structural similarities of its ABC transporters to mammalian ones. Numerous ABC transporters are found in humans and some are associated with the resistance of tumors to chemotherapeutics. Efflux pump modulators that change the activity of ABC proteins are the most promising candidate drugs to overcome such resistance. These modulators can be chemically synthesized or isolated from natural sources (e.g., plant alkaloids) and might also be used in the treatment of fungal infections. There are several generations of synthetic modulators that differ in specificity, toxicity and effectiveness, and are often used for other clinical effects.

Key words

ABC proteins PDR subfamily Saccharomyces cerevisiae Multidrug resistance Regulation of ABC proteins Transcription factors P-glycoprotein Modulators of ABC proteins Flavonoids Phenothiazines

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