Open Access

Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts

  • Gloria Gutiérrez-Venegas1Email author,
  • Oscar Alonso Luna1,
  • Juan Antonio Arreguín-Cano1 and
  • Cristina Hernández-Bermúdez1
Cellular & Molecular Biology LettersAn International Journal201419:186

https://doi.org/10.2478/s11658-014-0186-4

Received: 28 May 2013

Accepted: 18 February 2014

Published: 25 February 2014

Abstract

Periodontitis is an infectious disease caused by microorganisms present in dental bacterial plaque. Lipoteichoic acid (LTA) is a component of the external membrane of Gram-positive bacteria. It causes septic shock. Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins. In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis. We found that luteolin and myricetin blocked AKT and p38 activation and that myricetin blocked LTA-induced COX-2 expression. The results of our study are important for elucidating the mechanism of action of flavonoid regulation of inflammatory responses.

Keywords

Periodontitis Fisetin Morin Myricetin Luteolin Human gingival fibroblasts Lipoteichoic acid Cyclooxygenase

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