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Cellular & Molecular Biology Letters

Open Access

Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts

  • Gloria Gutiérrez-Venegas1Email author,
  • Oscar Alonso Luna1,
  • Juan Antonio Arreguín-Cano1 and
  • Cristina Hernández-Bermúdez1
Cellular & Molecular Biology LettersAn International Journal201419:186

Received: 28 May 2013

Accepted: 18 February 2014

Published: 25 February 2014


Periodontitis is an infectious disease caused by microorganisms present in dental bacterial plaque. Lipoteichoic acid (LTA) is a component of the external membrane of Gram-positive bacteria. It causes septic shock. Ingested flavonoids have been reported to directly affect the regulation of cyclooxygenase-2 (COX-2) expression induced by bacterial toxins. In this study, we examined the effects of four flavonoids (luteolin, fisetin, morin and myricetin) on the activation of ERK1/2, p38 and AKT, and on the synthesis of COX-2 in human gingival fibroblasts treated with LTA from Streptococcus sanguinis. We found that luteolin and myricetin blocked AKT and p38 activation and that myricetin blocked LTA-induced COX-2 expression. The results of our study are important for elucidating the mechanism of action of flavonoid regulation of inflammatory responses.


PeriodontitisFisetinMorinMyricetinLuteolinHuman gingival fibroblastsLipoteichoic acidCyclooxygenase