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The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue
Cellular & Molecular Biology Letters volume 19, pages 243–248 (2014)
We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.
artificial cerebrospinal fluid
excitatory postsynaptic potential
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Potkin, V.I., Shcharbin, D., Denisov, A.A. et al. The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue. Cell Mol Biol Lett 19, 243–248 (2014). https://doi.org/10.2478/s11658-014-0193-5
- Brain slices
- Postsynaptic potential
- Antitumor effects