Open Access

The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue

  • Vladimir I. Potkin1,
  • Dzmitry Shcharbin2, 6Email author,
  • Andrey A. Denisov3,
  • Svetlana G. Paschkevich3,
  • Maria Bryszewska4,
  • Sergey K. Petkevich1,
  • Alexey V. Kletskov1,
  • Dmitri O. Lapotko5,
  • Vladimir V. Kazbanov3,
  • Tatiana A. Gurinovich3 and
  • Vladimir A. Kulchitsky3
Cellular & Molecular Biology LettersAn International Journal201419:193

https://doi.org/10.2478/s11658-014-0193-5

Received: 2 October 2013

Accepted: 11 April 2014

Published: 24 April 2014

Abstract

We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid — to reduce oxygen consumption in transverse slices of the hippocampus taken from 4-week old male rats. In vitro electrophysiological experiments revealed that the inhibitory effect of the hypoxic state on the evoked responses was enhanced in the presence of the complexes. The data were analyzed in terms of the potential antitumor effects of these complexes.

Keywords

HypoxiaDendrimerBrain slicesPostsynaptic potentialAntitumor effectsHeterocyclesIsoxazoles

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