Open Access

Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer

Cellular & Molecular Biology LettersAn International Journal201419:203

https://doi.org/10.2478/s11658-014-0203-7

Received: 14 February 2014

Accepted: 21 July 2014

Published: 31 July 2014

Abstract

The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer.

Keywords

CancerGalectinsImmature laminin receptorOncofetal antigenPregnancy

Notes

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