Open Access

Regulation of lncRNA expression

  • Zhuomin Wu1,
  • Xiaoxia Liu1,
  • Li Liu1,
  • Houliang Deng1,
  • Jingjing Zhang1,
  • Qian Xu1,
  • Bohong Cen1 and
  • Aimin Ji1Email author
Cellular & Molecular Biology LettersAn International Journal201419:212

https://doi.org/10.2478/s11658-014-0212-6

Received: 19 June 2014

Accepted: 7 October 2014

Published: 13 October 2014

Abstract

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

Keywords

lncRNAsMechanismsDynamic expressionChromatin stateTranscription factorSpecific DNA sequencemicroRNAPost-transcriptional regulation

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