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Citation: Cellular & Molecular Biology Letters 2023 28:69
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Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously associated with lymph node metastasis of luminal A breast tumors and was found to incre...
Citation: Cellular & Molecular Biology Letters 2023 28:68 -
Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells
Prenatal infection has been implicated in the development of neuropsychiatric disorders in children. We hypothesised that exposure to lipopolysaccharide during prenatal development could induce anxiety-like be...
Citation: Cellular & Molecular Biology Letters 2023 28:67 -
MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
Endothelial dysfunction and deregulated microRNAs (miRNAs) participate in the development of sepsis and are associated with septic organ failure and death. Here, we explored the role of miR-15b-5p on inflammat...
Citation: Cellular & Molecular Biology Letters 2023 28:66 -
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
Peripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic pain (NeP). The mechanisms contributing to neuroinflammation remain poorly elucidated, ...
Citation: Cellular & Molecular Biology Letters 2023 28:65 -
Exogenous and endogenous dsRNAs perceived by plant Dicer-like 4 protein in the RNAi-depleted cellular context
In plants, RNase III Dicer-like proteins (DCLs) act as sensors of dsRNAs and process them into short 21- to 24-nucleotide (nt) (s)RNAs. Plant DCL4 is involved in the biogenesis of either functional endogenous ...
Citation: Cellular & Molecular Biology Letters 2023 28:64 -
Multi-omics strategies uncover the molecular mechanisms of nitrogen, phosphorus and potassium deficiency responses in Brassica napus
Nitrogen (N), phosphorus (P) and potassium (K) are critical macronutrients in crops, such that deficiency in any of N, P or K has substantial effects on crop growth. However, the specific commonalities of plan...
Citation: Cellular & Molecular Biology Letters 2023 28:63 -
Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO
Bladder cancer (BLCA) is a malignancy that frequently metastasizes and leads to poor patient prognosis. It is essential to understand the molecular mechanisms underlying the progression and metastasis of BLCA ...
Citation: Cellular & Molecular Biology Letters 2023 28:62 -
A frog peptide provides new strategies for the intervention against skin wound healing
Amphibian derived pro-healing peptides as molecular probes might provide a promising strategy for development of drug candidates and elucidation of cellular and molecular mechanisms of skin wound healing. A no...
Citation: Cellular & Molecular Biology Letters 2023 28:61 -
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis
Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and infla...
Citation: Cellular & Molecular Biology Letters 2023 28:60 -
Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
The dynamics of phosphatidylserine in the plasma membrane is a tightly regulated feature of eukaryotic cells. Phosphatidylserine (PS) is found preferentially in the inner leaflet of the plasma membrane. Disrup...
Citation: Cellular & Molecular Biology Letters 2023 28:59 -
Melanoma cells induce dedifferentiation and metabolic changes in adipocytes present in the tumor niche
One of the factors that affect the progression of melanoma is the tumor microenvironment, which consists of cellular elements, extracellular matrix, acidification, and a hypoxic state. Adipocytes are one of th...
Citation: Cellular & Molecular Biology Letters 2023 28:58 -
Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells
The preference for glucose oxidative mode has crucial impacts on various physiological activities, including determining stem cell fate. External mechanical factors can play a decisive role in regulating criti...
Citation: Cellular & Molecular Biology Letters 2023 28:57 -
Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line
Focal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways that control cell proliferation, differ...
Citation: Cellular & Molecular Biology Letters 2023 28:56 -
Hypothermic oxygenated perfusion attenuates DCD liver ischemia–reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress
Hepatic ischemia–reperfusion injury (IRI) in donation after cardiac death (DCD) donors is a major determinant of transplantation success. Endoplasmic reticulum (ER) stress plays a key role in hepatic IRI, with...
Citation: Cellular & Molecular Biology Letters 2023 28:55 -
γ-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core
The AMPA-type ionotropic glutamate receptor mediates fast excitatory neurotransmission in the brain. A variety of auxiliary subunits regulate its gating properties, assembly, and trafficking, but it is unknown...
Citation: Cellular & Molecular Biology Letters 2023 28:54 -
EFEMP2 upregulates PD-L1 expression via EGFR/ERK1/2/c-Jun signaling to promote the invasion of ovarian cancer cells
Fibulin-like extracellular matrix protein 2 (EFEMP2) has been reported to be related to the progression of various cancers. We have previously reported that EFEMP2 was highly expressed in ovarian cancer and wa...
Citation: Cellular & Molecular Biology Letters 2023 28:53 -
CKM and TERT dual promoters drive CRISPR–dCas9 to specifically inhibit the malignant behavior of osteosarcoma cells
Improvements in treatment and chemotherapy have increased the survival rate of osteosarcoma, but overall efficacy remains low, highlighting the need for new gene therapy methods. Clustered regularly interspace...
Citation: Cellular & Molecular Biology Letters 2023 28:52 -
The NLRP3 inflammasome: contributions to inflammation-related diseases
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple s...
Citation: Cellular & Molecular Biology Letters 2023 28:51 -
Notch mediates the glycolytic switch via PI3K/Akt signaling to support embryonic development
Energy metabolism disorder or insufficient energy supply during incubation will affect the development and survival of avian embryos. Especially, β-oxidation could not provide the continuous necessary energy f...
Citation: Cellular & Molecular Biology Letters 2023 28:50 -
A novel tyrosine tRNA-derived fragment, tRFTyr, induces oncogenesis and lactate accumulation in LSCC by interacting with LDHA
Transfer (t)RNA-derived small RNA (tsRNA), generated from precursor or mature tRNA, is a new type of small non-coding RNA (sncRNA) that has recently been shown to play a vital role in human cancers. However, i...
Citation: Cellular & Molecular Biology Letters 2023 28:49 -
PRDX1 negatively regulates bleomycin-induced pulmonary fibrosis via inhibiting the epithelial-mesenchymal transition and lung fibroblast proliferation in vitro and in vivo
Pulmonary fibrosis is a major category of end-stage changes in lung diseases, characterized by lung epithelial cell damage, proliferation of fibroblasts, and accumulation of extracellular matrix. Peroxiredoxin...
Citation: Cellular & Molecular Biology Letters 2023 28:48 -
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has...
Citation: Cellular & Molecular Biology Letters 2023 28:47 -
Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex
For cancer therapy, the identification of both selective autophagy targets and small molecules that specifically regulate autophagy is greatly needed. Heat shock protein 70 (Hsp70) is a recently discovered BH3...
Citation: Cellular & Molecular Biology Letters 2023 28:46 -
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment
CD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute myeloid leukemia (AML), we found that APOC2 acts with CD36 to promote leukem...
Citation: Cellular & Molecular Biology Letters 2023 28:45 -
An integrative review of nonobvious puzzles of cellular and molecular cardiooncology
Oncologic patients are subjected to four major treatment types: surgery, radiotherapy, chemotherapy, and immunotherapy. All nonsurgical forms of cancer management are known to potentially violate the structura...
Citation: Cellular & Molecular Biology Letters 2023 28:44 -
Comparison between 5 extractions methods in either plasma or serum to determine the optimal extraction and matrix combination for human metabolomics
Although metabolomics continues to expand in many domains of research, methodological issues such as sample type, extraction and analytical protocols have not been standardized, impeding proper comparison betw...
Citation: Cellular & Molecular Biology Letters 2023 28:43 -
Empagliflozin improves renal ischemia–reperfusion injury by reducing inflammation and enhancing mitochondrial fusion through AMPK–OPA1 pathway promotion
Renal ischemia–reperfusion injury (IRI) is one reason for renal transplantation failure. Recent studies have shown that mitochondrial dynamics is closely related to IRI, and that inhibition or reversal of mito...
Citation: Cellular & Molecular Biology Letters 2023 28:42 -
Profiling the impact of the promoters on CRISPR-Cas12a system in human cells
The plasmid vector platform is the most commonly used vector for the expression of the versatile CRISPR-Cas technique and the promoter is a crucial element for the expression vector, thus profiling the impact ...
Citation: Cellular & Molecular Biology Letters 2023 28:41 -
Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration
Deer antlers are the only known mammalian structure that undergoes full regeneration. In addition, it is peculiar because when growing, it contains vascularized cartilage. The differentiation of antler stem ce...
Citation: Cellular & Molecular Biology Letters 2023 28:40 -
Optogenetic control of YAP can enhance the rate of wound healing
Tissues need to regenerate to restore function after injury. Yet, this regenerative capacity varies significantly between organs and between species. For example, in the heart, some species retain full regener...
Citation: Cellular & Molecular Biology Letters 2023 28:39 -
Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intui...
Citation: Cellular & Molecular Biology Letters 2023 28:38 -
The role of noncoding RNAs in metabolic reprogramming of cancer cells
Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to alter metabolic reactions and nutrient uptake, thereby promoting tumor growth and spread. It has been discovered that no...
Citation: Cellular & Molecular Biology Letters 2023 28:37 -
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
Oral squamous cell carcinomas are one of the most common cancers worldwide with aggressive behavior and poor prognosis. Reactive oxygen species (ROS) are associated with cancer and cause various types of regul...
Citation: Cellular & Molecular Biology Letters 2023 28:36 -
Protection of melatonin treatment and combination with traditional antibiotics against septic myocardial injury
Heart failure is a common complication of sepsis with a high mortality rate. It has been reported that melatonin can attenuate septic injury due to various properties. On the basis of previous reports, this st...
Citation: Cellular & Molecular Biology Letters 2023 28:35 -
CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop
Breast cancer (BC) is a common threat to women. The continuous activation of nuclear factor kappa B (NF-κB) signaling pathway contributes to the development of BC. This study aimed to investigate the role of a...
Citation: Cellular & Molecular Biology Letters 2023 28:34 -
Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance
Hepatocellular carcinoma (HCC) is considered one of the greatest challenges to human life and is the most common form of liver cancer. Treatment of HCC depends on chemotherapy, radiotherapy, surgery, and immun...
Citation: Cellular & Molecular Biology Letters 2023 28:33 -
KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo–YAP pathway
N6-methyladenosine (m6A) has been shown to participate in various essential biological processes by regulating the level of target genes. However, the function of m6A modification mediated by KIAA1429 [alias vir....
Citation: Cellular & Molecular Biology Letters 2023 28:32 -
RPL21 interacts with LAMP3 to promote colorectal cancer invasion and metastasis by regulating focal adhesion formation
Metastasis is the leading cause of death among patients with colorectal cancer (CRC). Therefore, it is important to explore the molecular mechanisms of metastasis to develop effective therapeutic targets for C...
Citation: Cellular & Molecular Biology Letters 2023 28:31 -
Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?
Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) arise during the evolution o...
Citation: Cellular & Molecular Biology Letters 2023 28:30 -
Correction: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells
Citation: Cellular & Molecular Biology Letters 2023 28:29 -
Blood-based liquid biopsy: insights into early detection, prediction, and treatment monitoring of bladder cancer
Bladder cancer (BC) is a clinical challenge worldwide with late clinical presentation, poor prognosis, and low survival rates. Traditional cystoscopy and tissue biopsy are routine methods for the diagnosis, pr...
Citation: Cellular & Molecular Biology Letters 2023 28:28 -
IFN-γ blockade after genetic inhibition of PD-1 aggravates skeletal muscle damage and impairs skeletal muscle regeneration
Innate immune responses play essential roles in skeletal muscle recovery after injury. Programmed cell death protein 1 (PD-1) contributes to skeletal muscle regeneration by promoting macrophage proinflammatory...
Citation: Cellular & Molecular Biology Letters 2023 28:27 -
rt269L-Type hepatitis B virus (HBV) in genotype C infection leads to improved mitochondrial dynamics via the PERK–eIF2α–ATF4 axis in an HBx protein-dependent manner
In our previous report, the rt269I type versus the rt269L type in genotype C2 infection led to poor clinical outcomes and enhanced mitochondrial stress in infected hepatocytes. Here, we sought to investigate d...
Citation: Cellular & Molecular Biology Letters 2023 28:26 -
p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer
During cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and generates p20BAP31, which has been shown to induce an apoptotic pathway between the endoplasmic reticulum (ER) and mitochondria. Howev...
Citation: Cellular & Molecular Biology Letters 2023 28:25 -
Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Sepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of current therapeutic strategies and de...
Citation: Cellular & Molecular Biology Letters 2023 28:24 -
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of type IV P-tape ATPase (P4-ATPase), which is critical to maintain cellular stability and ...
Citation: Cellular & Molecular Biology Letters 2023 28:23 -
Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
Cerebral arteriovenous malformations (cAVM) are a significant cause of intracranial hemorrhagic stroke and brain damage. The arteriovenous junctions in AVM nidus are known to have hemodynamic disturbances such...
Citation: Cellular & Molecular Biology Letters 2023 28:22 -
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark...
Citation: Cellular & Molecular Biology Letters 2023 28:21 -
Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy
Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function. Our previous study has proved that miR-92a could ameliorat...
Citation: Cellular & Molecular Biology Letters 2023 28:20
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