Fig. 1
From: The functions and roles of sestrins in regulating human diseases
Roles of Sesns in human diseases. Sesns are proved to regulate cell metabolism and cellular homeostasis with their biological functions of protecting against various kinds of environmental stressors and regulating the AMPK/mTORC1 pathway. The protective and harmful effects of Sesns in various age-related diseases, metabolic disorders, and cancers are shown in this figure. COPD, chronic obstructive pulmonary disease; ER, endoplasmic reticulum; ECM, extracellular matrix