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Table 1 Studies that investigated the melatonin-induced modification of DNA methylation against cancer

From: Melatonin and cancer suppression: insights into its effects on DNA methylation

Cancer Type Cell line(s) Study Model and Dosage(s) Affected Gene(s) Ref.
Malignant glioma A172, U87, U373, and BTSCs In vitro, 0–1mM for 24 and 48 h ABCG2/BCRP [77]
Colorectal cancer Caco-2 In vitro, 1-100 nmol/L NF-κB, IL‐6, -8, COX‐2, and NO [79]
Breast cancer 4T1 In vivo (n = 12/group), 33 mg/L in drinking water Global DNA methylation [83]
Breast cancer MCF-7 In vitro, 1 and 100 nM EGR3, POU4F2/Brn-3b, and GPC3 [84]
Breast cancer 4T1 In vivo, 10 mg/L in drinking water Global DNA methylation [85]
Breast cancer MCF-7 In vitro 10 nM for 24 h, and In vivo (n = 3/group) 0.1 mg/mL in drinking water STAT3, IL-6, and ARH1 [90]
Breast cancer 4T1 In vivo (n = 10/group) 1.9 mg/kg/d Global DNA methylation [93]