Fig. 7
From: Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA–miRNA/protein axis
Influence of m6A modification of lncRNAs on tumorigenesis of GCSCs in vivo. A Schematic diagram for model mice with lncRNA-methylated GCSCs. B The tumor volume of the xenograft mice injected with METTL3-silenced GCSCs alone (control) or METTL3-silenced GCSCs with methylated PSMA3-AS1 or MIR22HG. C The size of solid tumors of the mice with METTL3-silenced GCSCs alone (control) or METTL3-silenced GCSCs with methylated PSMA3-AS1 or MIR22HG. D The weight of solid tumors of mice with METTL3-silenced GCSCs alone (control) or METTL3-silenced GCSCs with methylated PSMA3-AS1 or MIR22HG. E m6A levels of lncRNAs in the solid tumors of the mice injected with METTL3-silenced GCSCs alone (control) or METTL3-silenced GCSCs with methylated PSMA3-AS1 or MIR22HG. F Immunohistochemical analysis of the expressions of Ki67 and Caspase 3 in the solid tumors of the mice injected with METTL3-silenced GCSCs alone (control) or METTL3-silenced GCSCs with methylated PSMA3-AS1 or MIR22HG. G Detection of the expressions of stemness genes in solid tumors of the mice treated with the methylated PSMA3-AS1 or MIR22HG using Western blot. H Model for the roles of the methylated PSMA3-AS1 and MIR22HG in GCSCs. **, p < 0.01