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  1. Esophageal squamous cell carcinoma (ESCC) is correlated with worse clinical prognosis and lacks available targeted therapy. Thus, identification of reliable biomarkers is required for the diagnosis and treatme...

    Authors: Jinfeng Zhang, Xiaodong Ling, Chengyuan Fang and Jianqun Ma
    Citation: Cellular & Molecular Biology Letters 2022 27:39
    Content type: Research Published on:

  2. Designing and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotec...

    Authors: Armina Alagheband Bahrami, Ali Azargoonjahromi, Samin Sadraei, Aryan Aarabi, Zahra Payandeh and Masoumeh Rajabibazl
    Citation: Cellular & Molecular Biology Letters 2022 27:38
    Content type: Review Published on:

  3. In nature, lectins are widely dispersed proteins that selectively recognize and bind to carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral diseases have been treated w...

    Authors: Mohsen Nabi-Afjadi, Morteza Heydari, Hamidreza Zalpoor, Ibrahim Arman, Arezoo Sadoughi, Parisa Sahami and Safiyeh Aghazadeh
    Citation: Cellular & Molecular Biology Letters 2022 27:37
    Content type: Review Letter Published on:

  4. RING finger protein 7 (RNF7) is a highly conserved protein that functions as an E3 ubiquitin ligase. RNF7 overexpression is indicated in multiple human cancers, but its role in renal cell carcinoma (RCC) and t...

    Authors: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang and Qing Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:36
    Content type: Research Published on:

  5. The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/C...

    Authors: Sadegh Shojaei Baghini, Zhanna R. Gardanova, Saeme Azizi Hassan Abadi, Burhan Abdullah Zaman, Ahmet İlhan, Navid Shomali, Ali Adili, Roozbeh Moghaddar and Amirhossein Fakhre Yaseri
    Citation: Cellular & Molecular Biology Letters 2022 27:35
    Content type: Review Published on:

  6. Vital organ injury is one of the leading causes of global deaths. Accumulating studies have demonstrated that dexmedetomidine (DEX) has an outstanding protective effect on multiple organs for its antiinflammat...

    Authors: Shankun Zhao, Weizhou Wu, Xuezheng Lin, Maolei Shen, Zhenyu Yang, Sicong Yu and Yu Luo
    Citation: Cellular & Molecular Biology Letters 2022 27:34
    Content type: Review Letter Published on:

  7. Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to d...

    Authors: Mohsen Karami Fath, Kimiya Babakhaniyan, Maryam Zokaei, Azadeh Yaghoubian, Sadaf Akbari, Mahdieh Khorsandi, Asma Soofi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fateme Jalalifar, Ali Azargoonjahromi, Zahra Payandeh and Armina Alagheband Bahrami
    Citation: Cellular & Molecular Biology Letters 2022 27:33
    Content type: Review Letter Published on:

  8. Autophagy plays an essential role in maintaining cellular homeostasis and in the response to cellular stress. Autophagy is also involved in cell cycle progression, yet the relationship between these processes ...

    Authors: Alena Gschwind, Christian Marx, Marie D. Just, Paula Severin, Hannah Behring, Lisa Marx-Blümel, Sabine Becker, Linda Rothenburger, Martin Förster, James F. Beck and Jürgen Sonnemann
    Citation: Cellular & Molecular Biology Letters 2022 27:32
    Content type: Research Published on:

  10. Diabetic nephropathy (DN) is regarded as the main vascular complication of diabetes mellitus, directly affecting the outcome of diabetic patients. Inflammatory factors were reported to participate in the progr...

    Authors: Fei Wang, Wenting Hou, Xue Li, Lihong Lu, Ting Huang, Minmin Zhu and Changhong Miao
    Citation: Cellular & Molecular Biology Letters 2022 27:30
    Content type: Research Published on:

  11. Acute lung injury (ALI) has received considerable attention in the field of intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in citrus fruits, is a natural bioactive ...

    Authors: Jin Li, Shi-hua Deng, Jing Li, Li Li, Feng Zhang, Ye Zou, Dong-ming Wu and Ying Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:29
    Content type: Research Published on:

  12. Parecoxib plays an important role in inhibition of human cancer. However, the effect of parecoxib on esophageal squamous cell carcinoma (ESCC) is still not well known. The purpose of this study was to investig...

    Authors: Han-Ming Huang, Xiao-Yu Huang, Shao-Ping Wu, Can-Keng Chen, Xin-Hua He and Yong-Fa Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:28
    Content type: Research Letter Published on:

  13. After spinal cord injury (SCI), dysregulated or nonresolving inflammatory processes can severely disturb neuronal homeostasis and drive neurodegeneration. Although mesenchymal stromal cell (MSC)-based therapie...

    Authors: Tianyun Gao, Feifei Huang, Wenqing Wang, Yuanyuan Xie and Bin Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:27
    Content type: Research Published on:

  14. N6-methyladenosine (m6A) is the most common and abundant internal modification of RNA. Its critical functions in multiple physiological and pathological processes have been reported. However, the role of m6A in s...

    Authors: Wenqing Sun, Yan Li, Dongyu Ma, Yi Liu, Qi Xu, Demin Cheng, Guanru Li and Chunhui Ni
    Citation: Cellular & Molecular Biology Letters 2022 27:26
    Content type: Research Published on:

  15. Accumulating evidence indicates that miR-5195-3p exerts tumor-suppressive roles in several tumors. However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been ...

    Authors: Xing Zeng, Zhiquan Hu, Yuanqing Shen, Xian Wei, Jiahua Gan and Zheng Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:25
    Content type: Research Letter Published on:

  16. Transmembrane protein 43 (TMEM43), a member of the transmembrane protein subfamily, plays a critical role in the initiation and development of cancers. However, little is known concerning the biological functi...

    Authors: Junqiang Li, Yang Song, Chao Zhang, Ronglin Wang, Lei Hua, Yongdong Guo, Dongxue Gan, Liaoliao Zhu, Shanshan Li, Peixiang Ma, Cheng Yang, Hong Li, Jing Yang, Jingjie Shi, Xiaonan Liu and Haichuan Su
    Citation: Cellular & Molecular Biology Letters 2022 27:24
    Content type: Research Published on:

  17. ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive...

    Authors: María Victoria Castro, Gastón Alexis Barbero, Paula Máscolo, Rocío Ramos, María Josefina Quezada and Pablo Lopez-Bergami
    Citation: Cellular & Molecular Biology Letters 2022 27:23
    Content type: Research Letter Published on:

  19. Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequac...

    Authors: Mina Homayoonfal, Zatollah Asemi and Bahman Yousefi
    Citation: Cellular & Molecular Biology Letters 2022 27:21
    Content type: Review Published on:

  20. EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR mono...

    Authors: Donatella Romaniello, Valerio Gelfo, Federica Pagano, Enea Ferlizza, Michela Sgarzi, Martina Mazzeschi, Alessandra Morselli, Carmen Miano, Gabriele D’Uva and Mattia Lauriola
    Citation: Cellular & Molecular Biology Letters 2022 27:20
    Content type: Research Letter Published on:

  21. Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promo...

    Authors: Yi-Fang Yang, Chuang-Ming Wang, I.-Hsin Hsiao, Yi-Liang Liu, Wen-Hao Lin, Chih-Li Lin, Hui-Chih Hung and Guang-Yaw Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:19
    Content type: Research Published on:

  23. Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms are not well characterized.

    Authors: Le Lu, Jingjing Huang, Jiantao Mo, Xuanbo Da, Qiaoxin Li, Meng Fan and Hongwei Lu
    Citation: Cellular & Molecular Biology Letters 2022 27:17
    Content type: Research Published on:

  24. Allergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin inflammation and a mixed itch and pain sensation. The itch and pain dr...

    Authors: Boyu Liu, Ruixiang Chen, Jie Wang, Yuanyuan Li, Chengyu Yin, Yan Tai, Huimin Nie, Danyi Zeng, Junfan Fang, Junying Du, Yi Liang, Xiaomei Shao, Jianqiao Fang and Boyi Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:16
    Content type: Research Letter Published on:

  26. MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an ...

    Authors: Arash Letafati, Sajad Najafi, Mehran Mottahedi, Mohammad Karimzadeh, Ali Shahini, Setareh Garousi, Mohammad Abbasi-Kolli, Javid Sadri Nahand, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Neda Rahimian, Mohammad Taghizadieh and Hamed Mirzaei
    Citation: Cellular & Molecular Biology Letters 2022 27:14
    Content type: Review Published on:

  27. In recent years, morbidity and mortality of prostate cancer (PCa) have increased dramatically, while mechanistic understanding of its onset and progression remains unmet. LncRNA SNHG3 has been proved to stimul...

    Authors: Xiaotian Wang, Yongsheng Song, Yaxing Shi, Da Yang, Jiaxing Li and Bo Yin
    Citation: Cellular & Molecular Biology Letters 2022 27:13
    Content type: Research Published on:

  28. The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucle...

    Authors: Silvia Chichiarelli, Fabio Altieri, Giuliano Paglia, Elisabetta Rubini, Marco Minacori and Margherita Eufemi
    Citation: Cellular & Molecular Biology Letters 2022 27:12
    Content type: Invited Review Published on:

  30. The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronaviru...

    Authors: Hamidreza Zalpoor, Abdullatif Akbari, Azam Samei, Razieh Forghaniesfidvajani, Monireh Kamali, Azadeh Afzalnia, Shirin Manshouri, Fatemeh Heidari, Majid Pornour, Majid Khoshmirsafa, Hossein Aazami and Farhad Seif
    Citation: Cellular & Molecular Biology Letters 2022 27:10
    Content type: Review Letter Published on:

  31. Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survi...

    Authors: M. Kanmalar, Siti Fairus Abdul Sani, Nur Izzahtul Nabilla B. Kamri, Nur Akmarina B. M. Said, Amirah Hajirah B. A. Jamil, S. Kuppusamy, K. S. Mun and D. A. Bradley
    Citation: Cellular & Molecular Biology Letters 2022 27:9
    Content type: Review Published on:

  32. Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, a polylactosamine synthase, is an important member of the glycosyltransferase family. However, the biological ...

    Authors: Zhiguo Luo, Qing Hu, Yuanhui Tang, Yahui Leng, Tian Tian, Shuangyue Tian, Chengyang Huang, Ao Liu, Xinzhou Deng and Li Shen
    Citation: Cellular & Molecular Biology Letters 2022 27:8
    Content type: Research Published on:

  33. Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signal...

    Authors: Hongjuan You, Qi Li, Delong Kong, Xiangye Liu, Fanyun Kong, Kuiyang Zheng and Renxian Tang
    Citation: Cellular & Molecular Biology Letters 2022 27:7
    Content type: Review Letter Published on:

  34. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate. The majority of deaths in this disease are caused...

    Authors: Mohammad Rafi Khezri, Reza Varzandeh and Morteza Ghasemnejad-Berenji
    Citation: Cellular & Molecular Biology Letters 2022 27:6
    Content type: Review Letter Published on:

  35. Osteosarcoma (OS) is a common primary bone malignancy. Long noncoding RNA HCG18 is known to play an important role in a variety of cancers. However, its role in OS and relevant molecular mechanisms are unclear.

    Authors: Xiaohui Pan, Jin Guo, Canjun Liu, Zhanpeng Pan, Zhicheng Yang, Xiang Yao and Jishan Yuan
    Citation: Cellular & Molecular Biology Letters 2022 27:5
    Content type: Research Published on:

  36. Leaf senescence is an integral part of plant development and is driven by endogenous cues such as leaf or plant age. Developmental senescence aims to maximize the usage of carbon, nitrogen and mineral resource...

    Authors: Ulrike Zentgraf, Ana Gabriela Andrade-Galan and Stefan Bieker
    Citation: Cellular & Molecular Biology Letters 2022 27:4
    Content type: Invited Review Published on:

  37. Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). However, VDR-mediated transcriptional modulation does n...

    Authors: Anna M. Olszewska, Adam K. Sieradzan, Piotr Bednarczyk, Adam Szewczyk and Michał A. Żmijewski
    Citation: Cellular & Molecular Biology Letters 2022 27:3
    Content type: Research Letter Published on:

  38. Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum ...

    Authors: Yitong Chen, Tingben Huang, Zhou Yu, Qiong Yu, Ying Wang, Ji’an Hu, Jiejun Shi and Guoli Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:2
    Content type: Review Letter Published on:

  39. Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to failure of treatment and recurrence of the disease. ...

    Authors: Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi and Bahman Yousefi
    Citation: Cellular & Molecular Biology Letters 2022 27:1
    Content type: Review Letter Published on:

  41. This study evaluated microRNA-148a-3p in esophageal carcinoma cells. The prediction of bioinformatics analysis revealed that microRNA-148a-3p may target CEP55. qRT-PCR and western blot showed that CEP55 level ...

    Authors: Yong Lin, Yushan Chen, Rongqiang Shen, Dingzhu Chen and Yimin Lin
    Citation: Cellular & Molecular Biology Letters 2021 26:54
    Content type: Research Letter Published on:

  42. Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2...

    Authors: Lucia Haronikova, Ondrej Bonczek, Pavlina Zatloukalova, Filip Kokas-Zavadil, Martina Kucerikova, Philip J. Coates, Robin Fahraeus and Borivoj Vojtesek
    Citation: Cellular & Molecular Biology Letters 2021 26:53
    Content type: Invited Review Published on:

  44. Ovarian cancer is a devastating gynecological malignancy and frequently presents as an advanced carcinoma with disseminated peritoneum metastasis. Acacetin exerts anti-cancerous effects in several carcinomas. ...

    Authors: Meng Tian, Yingjie Tang, Ting Huang, Yang Liu and Yingzheng Pan
    Citation: Cellular & Molecular Biology Letters 2021 26:51
    Content type: Research Letter Published on:

  45. Esterase D (ESD) is a nonspecific esterase that detoxifies formaldehyde. Many reports have stated that ESD activity is associated with a variety of physiological and pathological processes. However, the detail...

    Authors: Yuejun Yang, Xinpeng Chen, Wen Yao, Xiaoling Cui, Na Li, ZhaoMin Lin, Baoxiang Zhao and Junying Miao
    Citation: Cellular & Molecular Biology Letters 2021 26:50
    Content type: Research Published on:

  46. Hepatocellular carcinoma (HCC) is now the second leading cause of cancer death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and metastasis. The aim of this study was to invest...

    Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang and Hongyi Zhang
    Citation: Cellular & Molecular Biology Letters 2021 26:49
    Content type: Research Letter Published on:

  47. Intestinal mucositis is a common side effect of chemotherapy and radiotherapy. Very few drugs can efficiently ameliorate it. Tertiary butylhydroquinone (TBHQ) is a widely used food preservative with known immu...

    Authors: Shihua Deng, Dongming Wu, Li Li, Jin Li and Ying Xu
    Citation: Cellular & Molecular Biology Letters 2021 26:48
    Content type: Research Letter Published on:

  48. Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a majo...

    Authors: Xiao-Yu He, Hai-Ming Yu, Shu Lin and Yi-Zhong Li
    Citation: Cellular & Molecular Biology Letters 2021 26:47
    Content type: Review Published on:

  49. Epigenetics refers to nucleotide sequence-independent events, and heritable changes, including DNA methylation and histone modification (as the two main processes), contributing to the phenotypic features of t...

    Authors: Raheleh Halabian, Valizadeh Arshad, Ali Ahmadi, Pardis Saeedi, Sadegh Azimzadeh Jamalkandi and Mohammad Reza Alivand
    Citation: Cellular & Molecular Biology Letters 2021 26:46
    Content type: Review Published on:

  50. Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many c...

    Authors: Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou and Erhao Zhang
    Citation: Cellular & Molecular Biology Letters 2021 26:45
    Content type: Research Published on:

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