Articles

β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling

Alkannin-based pharmaceutical formulations for improving wound healing have been on the market for several years. However, detailed molecular mechanisms of their action have yet to be elucidated. Here, we i...

Authors: Xiao Yang, Weijing Fan, Renyan Huang and Guobin Liu

Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation

Burn injury is one of the potential causes of heterotopic ossification (HO), which is a rare but debilitating condition. The incidence ranges from 3.5 to 5.6 depending on body area. Burns that cover a larger p...

Authors: Xianglin Hu, Zhengwang Sun, Fengfeng Li, Chaoyin Jiang, Wangjun Yan and Yangbai Sun

LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis

Long noncoding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1) is aberrantly expressed in multiple cancers and has been verified as an oncogene. However, the underlying mechanism of UCA1 in the developm...

Authors: An Yang, Xin Liu, Ping Liu, Yunzhang Feng, Hongbo Liu, Shen Gao, Limin Huo, Xinyan Han, Jurong Wang and Wei Kong

Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease

In the past decade, G protein-coupled receptors have emerged as drug targets, and their physiological and pathological effects have been extensively studied. Among these receptors, GPR119 is expressed in multi...

Authors: Jianan Zhao, Yu Zhao, Yiyang Hu and Jinghua Peng

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer mic...

Authors: Meng Li, Di Zhong and Guozhong Li

Macrophage polarization by MSC-derived CXCL12 determines tumor growth

Phenotypic and functional heterogeneity of macrophages is known to be the main reason for their ability to regulate inflammation and promote tumorigenesis. Mesenchymal stem cells (MSCs) are one of the principa...

Authors: Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah and Mohamad Zamani-Ahmadmahmudi

Autophagy receptors as viral targets

Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles...

Authors: Päivi Ylä-Anttila

β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

We have previously found that β-elemene could inhibit the viability of airway granulation fibroblasts and prevent airway hyperplastic stenosis. This study aimed to elucidate the underlying mechanism and protec...

Authors: Guoying Zhang, Cheng Xue and Yiming Zeng

LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis

Although lncRNA TP73-AS1 has been shown to play important roles in various human diseases, its function in atherosclerosis (AS) remains unclear.

Authors: Jia Ni, Zhen Huang and Dan Wang

Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling

Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription fact...

Authors: Dazhi Fu, Chunxiao Wang, Lei Yu and Rui Yu

Circular RNA expression profile in transgenic diabetic mouse kidneys

Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNA...

Authors: Xuan Xiong, Changchun Liu, Meiren Shen, Qian Yang, Qiang Zhao, Xiaoyan Li, Xiaoshi Zhong and Zhiwei Wang

Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A

The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p in pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

Authors: Yanfen Lian, Dongxiao Jiang and Jiangtao Sun

Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells

Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This stu...

Authors: Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo and Jin Wang

LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions

Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differ...

Authors: Xiaozhong Zhou, Wangyang Xu, Yeyang Wang, Hui Zhang, Li Zhang, Chao Li, Shun Yao, Zixiang Huang, Lishan Huang and Dixin Luo

miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop

Recently, pivotal functions of miRNAs in regulating common tumorigenic processes and manipulating signaling pathways in brain tumors have been recognized; notably, miR‐29a is closely associated with p53 signal...

Authors: Qiudan Chen, Weifeng Wang, Shuying Chen, Xiaotong Chen and Yong Lin

MiR-501 promotes tumor proliferation and metastasis by targeting HOXD10 in endometrial cancer

Several studies have shown the crucial role of miR-501 in regulating cellular pathology in various cancers. However, the function and expression of miR-501 in endometrial cancer (EC) remain obscure.

Authors: Xiaomei Sun, Lingtong Hou, Chunping Qiu and Beihua Kong

Worenine reverses the Warburg effect and inhibits colon cancer cell growth by negatively regulating HIF-1α

Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological effects and mechanisms of worenine (is...

Authors: Lijiang Ji, Weixing Shen, Feng Zhang, Jie Qian, Jie Jiang, Liping Weng, Jiani Tan, Liu Li, Yugen Chen, Haibo Cheng and Dongdong Sun

mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types

Mammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mT...

Authors: Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska and Jacek Jaworski

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and compiled the most recent research into po...

Authors: Jianan Zhao, Yiyang Hu and Jinghua Peng

Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation

In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas G...

Authors: Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan and Hiroaki Konishi

Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells

Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport.

Authors: Bing Sun, Rongmei Qu, Tingyu Fan, Yuchao Yang, Xin Jiang, Asmat Ullah Khan, Zhitao Zhou, Jingliao Zhang, Kuanhai Wei, Jun Ouyang and Jingxing Dai

Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival

The expression signature of deregulated long non-coding RNAs (lncRNAs) and related genetic variants is implicated in every stage of tumorigenesis, progression, and recurrence. This study aimed to explore the a...

Authors: Shahad W. Kattan, Yahya H. Hobani, Sameerah Shaheen, Sara H. Mokhtar, Mohammad H. Hussein, Eman A. Toraih, Manal S. Fawzy and Hussein Abdelaziz Abdalla

Molecular interactions of miR-338 during tumor progression and metastasis

Cancer, as one of the main causes of human deaths, is currently a significant global health challenge. Since the majority of cancer-related deaths are associated with late diagnosis, it is necessary to develop...

Authors: Meysam Moghbeli

Relationship between miR-378c and YY1 expression in patients with gastric cancer and the clinicopathological features

The purpose of this study was to explore the clinical value of miR-378c and its target gene YY1 in gastric cancer.

Authors: Lei Zhang, Lei Zou and Peng Sun

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell surv...

Authors: Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn and Rafal Bartoszewski

Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease

Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation...

Authors: Marcin Woźniak, Christian J. Konopka, Agata Płoska, Jamila Hedhli, Anna Siekierzycka, Maciej Banach, Rafal Bartoszewski, Lawrence W. Dobrucki, Leszek Kalinowski and Iwona T. Dobrucki

Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating d...

Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang and Lining Wei

Retraction Note to: Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s11658-021-00252-1

Authors: Yan Hao, Haitao Yuan and Houzhi Yu

The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation

NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4⁺ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4⁺IL22⁺IFNγ⁻IL17A⁻) cells are a subgroup o...

Authors: Chong Zeng, Zhongbao Shao, Zibo Wei, Jie Yao, Weidong Wang, Liang Yin, Huixian YangOu and Dan Xiong

ZNF674-AS1 antagonizes miR-423-3p to induce G0/G1 cell cycle arrest in non-small cell lung cancer cells

ZNF674-AS1, a recently characterized long noncoding RNA, shows prognostic significance in hepatocellular carcinoma and glioma. However, the expression and function of ZNF674-AS1 in non-small cell lung cancer (...

Authors: Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin and Liangcheng Zheng

Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns

The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological dise...

Authors: Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schiöth and Robert Fredriksson

Enhancer RNAs: transcriptional regulators and workmates of NamiRNAs in myogenesis

miRNAs are well known to be gene repressors. A newly identified class of miRNAs termed nuclear activating miRNAs (NamiRNAs), transcribed from miRNA loci that exhibit enhancer features, promote gene expression ...

Authors: Emmanuel Odame, Yuan Chen, Shuailong Zheng, Dinghui Dai, Bismark Kyei, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li and Hongping Zhang

Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines

Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppre...

Authors: Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu and Xuerong Chen

Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin

Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcu...

Authors: Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu and Siqian Wang

Beyond K48 and K63: non-canonical protein ubiquitination

Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly regulated proteolysis, ubiquitination is now regard...

Authors: Michal Tracz and Wojciech Bialek

In vitro differentiation of W8B2⁺ human cardiac stem cells: gene expression of ionic channels and spontaneous calcium activity

Human cardiac stem cells expressing the W8B2 marker (W8B2⁺ CSCs) were recently identified and proposed as a new model of multipotent CSCs capable of differentiating into smooth muscle cells, endothelial cells and...

Authors: Oualid Ayad, Zeina R. Al Sayed, Stéphane Sebille, Christophe Magaud, Charles-Albert Chapotte-Baldacci, Christophe Jayle, Jean-François Faivre, Nathalie Gaborit, Aurélien Chatelier and Patrick Bois

MicroRNA-296-5p inhibits cell metastasis and invasion in nasopharyngeal carcinoma by reversing transforming growth factor-β-induced epithelial–mesenchymal transition

To explore the effect of miR-296-5p on the metastasis of nasopharyngeal carcinoma (NPC) cells and investigate the underlying mechanism.

Authors: Meihui Chen, Chen Chen, Haiqing Luo, Jing Ren, Qiuqin Dai, Wenjia Hu, Keyuan Zhou, Xudong Tang and Xiangyong Li

The nuclear receptor 4A family members: mediators in human disease and autophagy

The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involveme...

Authors: Liqun Chen, Fengtian Fan, Lingjuan Wu and Yiyi Zhao

hsa_circ_0006916 promotes hepatocellular carcinoma progression by activating the miR-337-3p/STAT3 axis

Circular RNAs (circRNAs) are thought to be involved in the development of various malignancies. The expression and function of hsa_circ_0006916, a newly identified circRNA, in hepatocellular carcinoma remain u...

Authors: Xiao-Yong Zhou, Hui Yang, Yang-Qiu Bai, Xiu-Ling Li, Shuang-Yin Han and Bing-Xi Zhou

Obituary: in memory of Professor Tadeusz Chojnacki (1932–2020)

Authors: Ewa Swiezewska and Anna Chojnacka

Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT

Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a key mechanism in pulmonary arterial hypertension (PAH). Serotonin (5-hydroxytryptamine, 5-HT) can induce abnormal proliferation of P...

Authors: Ying Zhang, Yongbin Chen, Guo Chen, Yingling Zhou, Hua Yao and Hong Tan

Arsenic trioxide as a novel anti-glioma drug: a review

Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regu...

Authors: Yi Fang and Zhen Zhang

Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1

Long intergenic non-protein coding RNA00665 (LINC00665) plays a crucial tumorigenic role in many cancers, such as gastric cancer and lung adenocarcinoma. However, its role and mechanism of action in the progre...

Authors: Minhao Lv, Qixin Mao, Juntao Li, Jianghua Qiao, Xiuchun Chen and Suxia Luo

Comparative transcriptome analysis of the main beam and brow tine of sika deer antler provides insights into the molecular control of rapid antler growth

Deer antlers have become a valuable model for biomedical research due to the capacities of regeneration and rapid growth. However, the molecular mechanism of rapid antler growth remains to be elucidated. The a...

Authors: Baojin Yao, Chaonan Wang, Zhenwei Zhou, Mei Zhang, Daqing Zhao, Xueyuan Bai and Xiangyang Leng

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...

Authors: Ruidong Li, Pavlina Zatloukalova, Petr Muller, Maria Gil-Mir, Sachin Kote, Simon Wilkinson, Alain J. Kemp, Lenka Hernychova, Yaxin Wang, Kathryn L. Ball, Kaixiong Tao, Ted Hupp and Borivoj Vojtesek

Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

Animal model studies show that reductive stress is involved in cardiomyopathy and myopathy, but the exact physiological relevance remains unknown. In addition, the microRNAs miR-143 and miR-145 have been shown...

Authors: Kota Ogawa, Akiko Noda, Jun Ueda, Takehiro Ogata, Rumiko Matsuyama, Yuji Nishizawa, Shanlou Qiao, Satoru Iwata, Morihiro Ito, Yoshitaka Fujihara, Masatoshi Ichihara, Koichi Adachi, Yuji Takaoka and Takashi Iwamoto

Specific functions of Exostosin-like 3 (EXTL3) gene products

Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the anim...

Authors: Shuhei Yamada

Effects of HPV16 E6 protein on Daxx-induced apoptosis in C33A cells

Daxx is a highly conserved nuclear protein with an important role in transcription, apoptosis and other cell processes. We investigated the role of HPV16 E6 in Daxx-induced apoptosis through their interactions...

Authors: Shuangyang Tang, Shuang Ding, Lan Yu, Haiyan Shen, Yanping Wan and Yimou Wu

Do ABC transporters regulate plasma membrane organization?

The plasma membrane (PM) spatiotemporal organization is one of the major factors controlling cell signaling and whole-cell homeostasis. The PM lipids, including cholesterol, determine the physicochemical prope...

Authors: Ambroise Wu, Karolina Wojtowicz, Stephane Savary, Yannick Hamon and Tomasz Trombik

Silibinin suppresses epithelial–mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1

Rhomboid domain containing 1 (RHBDD1) plays a crucial role in tumorigenesis. Silibinin, which is a natural extract from milk thistle, has shown anti-tumor effects against various tumors. Here, we investigate w...

Authors: Suyan Xu, Hongyan Zhang, Aifeng Wang, Yongcheng Ma, Yuan Gan and Guofeng Li