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  1. Hepatocellular carcinoma (HCC) is now the second leading cause of cancer death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and metastasis. The aim of this study was to invest...

    Authors: Ying Xing, Yang Liu, Zhong Qi, Zhengrong Liu, Xin Wang and Hongyi Zhang

    Citation: Cellular & Molecular Biology Letters 2021 26:49

    Content type: Research Letter

    Published on:

  2. Intestinal mucositis is a common side effect of chemotherapy and radiotherapy. Very few drugs can efficiently ameliorate it. Tertiary butylhydroquinone (TBHQ) is a widely used food preservative with known immu...

    Authors: Shihua Deng, Dongming Wu, Li Li, Jin Li and Ying Xu

    Citation: Cellular & Molecular Biology Letters 2021 26:48

    Content type: Research Letter

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  3. Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a majo...

    Authors: Xiao-Yu He, Hai-Ming Yu, Shu Lin and Yi-Zhong Li

    Citation: Cellular & Molecular Biology Letters 2021 26:47

    Content type: Review

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  4. Epigenetics refers to nucleotide sequence-independent events, and heritable changes, including DNA methylation and histone modification (as the two main processes), contributing to the phenotypic features of t...

    Authors: Raheleh Halabian, Valizadeh Arshad, Ali Ahmadi, Pardis Saeedi, Sadegh Azimzadeh Jamalkandi and Mohammad Reza Alivand

    Citation: Cellular & Molecular Biology Letters 2021 26:46

    Content type: Review

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  5. Liquid–liquid phase separation (LLPS) within the nucleus is directly linked to driving gene expression through transcriptional complexes. Histone lysine methyltransferase 2D (KMT2D) is widely present in many c...

    Authors: Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou and Erhao Zhang

    Citation: Cellular & Molecular Biology Letters 2021 26:45

    Content type: Research

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  6. Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management. Surprisingly, the effect o...

    Authors: Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik and Krzysztof Książek

    Citation: Cellular & Molecular Biology Letters 2021 26:44

    Content type: Research

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  8. Keratinocytes and fibroblasts represent the major cell types in the epidermis and dermis of the skin and play a significant role in maintenance of skin homeostasis. However, the biological characteristics of k...

    Authors: Tiancheng Wang, Zhenwei Zhou, Enjing Luo, Jinghong Zhong, Daqing Zhao, Haisi Dong and Baojin Yao

    Citation: Cellular & Molecular Biology Letters 2021 26:42

    Content type: Research Letter

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  9. More powerful prognostic and diagnostic tools are urgently needed for identifying and treating ovarian cancer (OC), which is the most fatal malignancy in women in developed countries. Circular RNAs (circRNAs) ...

    Authors: Zahra Foruzandeh, Fatemeh Zeinali-Sehrig, Kazem Nejati, Dara Rahmanpour, Fariba Pashazadeh, Farhad Seif and Mohammad Reza Alivand

    Citation: Cellular & Molecular Biology Letters 2021 26:41

    Content type: Review Letter

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  10. Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia r...

    Authors: Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang, Weiheng Wen, Weiqiang Jiang, Hong Chen, Donghui Liang, Jia Sun and Ming Wang

    Citation: Cellular & Molecular Biology Letters 2021 26:40

    Content type: Research

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  12. Neurological disorders are considered one of the greatest burdens to global public health and a leading cause of death. Stem cell therapies hold great promise for the cure of neurological disorders, as stem ce...

    Authors: Michal Arad, Robert A. Brown, Raju Khatri, Rodney J. Taylor and Michal Zalzman

    Citation: Cellular & Molecular Biology Letters 2021 26:38

    Content type: Research

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  13. Iron overload can promote the development of osteoporosis by inducing apoptosis in osteoblasts. However, the mechanism by which miRNAs regulate apoptosis in osteoblasts under iron overload has not been elucida...

    Authors: Yi Feng, Pei-Yan He, Wei-Dong Kong, Wan-Jing Cen, Peng-Lin Wang, Chang Liu, Wu Zhang, Shu-Shu Li and Jian-Wei Jiang

    Citation: Cellular & Molecular Biology Letters 2021 26:37

    Content type: Research Letter

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  14. Inflammatory bowel disease (IBD) is a kind of intestinal immune dysfunction disease, and its occurrence and prevalence are on the rise worldwide. As a chronic gastrointestinal disease, its pathogenesis is stil...

    Authors: Jing Shao, Yan Jin, Chunhong Shao, Hui Fan, Xiaorui Wang and Guang Yang

    Citation: Cellular & Molecular Biology Letters 2021 26:36

    Content type: Research Letter

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  15. Alkannin-based pharmaceutical formulations for improving wound healing have been on the market for several years. However, detailed molecular mechanisms of their action have yet to be elucidated. Here, we i...

    Authors: Xiao Yang, Weijing Fan, Renyan Huang and Guobin Liu

    Citation: Cellular & Molecular Biology Letters 2021 26:35

    Content type: Research Letter

    Published on:

  16. Burn injury is one of the potential causes of heterotopic ossification (HO), which is a rare but debilitating condition. The incidence ranges from 3.5 to 5.6 depending on body area. Burns that cover a larger p...

    Authors: Xianglin Hu, Zhengwang Sun, Fengfeng Li, Chaoyin Jiang, Wangjun Yan and Yangbai Sun

    Citation: Cellular & Molecular Biology Letters 2021 26:34

    Content type: Review Letter

    Published on:

  17. Long noncoding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1) is aberrantly expressed in multiple cancers and has been verified as an oncogene. However, the underlying mechanism of UCA1 in the developm...

    Authors: An Yang, Xin Liu, Ping Liu, Yunzhang Feng, Hongbo Liu, Shen Gao, Limin Huo, Xinyan Han, Jurong Wang and Wei Kong

    Citation: Cellular & Molecular Biology Letters 2021 26:33

    Content type: Research

    Published on:

  18. In the past decade, G protein-coupled receptors have emerged as drug targets, and their physiological and pathological effects have been extensively studied. Among these receptors, GPR119 is expressed in multi...

    Authors: Jianan Zhao, Yu Zhao, Yiyang Hu and Jinghua Peng

    Citation: Cellular & Molecular Biology Letters 2021 26:32

    Content type: Review

    Published on:

  20. Phenotypic and functional heterogeneity of macrophages is known to be the main reason for their ability to regulate inflammation and promote tumorigenesis. Mesenchymal stem cells (MSCs) are one of the principa...

    Authors: Shabnam Babazadeh, Seyed Mahdi Nassiri, Vahid Siavashi, Mohadeseh Sahlabadi, Mostafa Hajinasrollah and Mohamad Zamani-Ahmadmahmudi

    Citation: Cellular & Molecular Biology Letters 2021 26:30

    Content type: Research Letter

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  21. Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles...

    Authors: Päivi Ylä-Anttila

    Citation: Cellular & Molecular Biology Letters 2021 26:29

    Content type: Review Letter

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  24. Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to investigate the function of activating transcription fact...

    Authors: Dazhi Fu, Chunxiao Wang, Lei Yu and Rui Yu

    Citation: Cellular & Molecular Biology Letters 2021 26:26

    Content type: Research

    Published on:

  25. Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis of diabetic nephropathy remain unclear. Several studies have indicated that circular RNA...

    Authors: Xuan Xiong, Changchun Liu, Meiren Shen, Qian Yang, Qiang Zhao, Xiaoyan Li, Xiaoshi Zhong and Zhiwei Wang

    Citation: Cellular & Molecular Biology Letters 2021 26:25

    Content type: Research Letter

    Published on:

  26. The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p in pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

    Authors: Yanfen Lian, Dongxiao Jiang and Jiangtao Sun

    Citation: Cellular & Molecular Biology Letters 2021 26:24

    Content type: Research

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  27. Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This stu...

    Authors: Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo and Jin Wang

    Citation: Cellular & Molecular Biology Letters 2021 26:23

    Content type: Research Letter

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  28. Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for regenerating articular cartilage. MiR-127-5p has been reported to promote cartilage differ...

    Authors: Xiaozhong Zhou, Wangyang Xu, Yeyang Wang, Hui Zhang, Li Zhang, Chao Li, Shun Yao, Zixiang Huang, Lishan Huang and Dixin Luo

    Citation: Cellular & Molecular Biology Letters 2021 26:22

    Content type: Research

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  29. Recently, pivotal functions of miRNAs in regulating common tumorigenic processes and manipulating signaling pathways in brain tumors have been recognized; notably, miR‐29a is closely associated with p53 signal...

    Authors: Qiudan Chen, Weifeng Wang, Shuying Chen, Xiaotong Chen and Yong Lin

    Citation: Cellular & Molecular Biology Letters 2021 26:21

    Content type: Research Letter

    Published on:

  31. Some natural compounds inhibit cancer cell growth in various cancer cell lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological effects and mechanisms of worenine (is...

    Authors: Lijiang Ji, Weixing Shen, Feng Zhang, Jie Qian, Jie Jiang, Liping Weng, Jiani Tan, Liu Li, Yugen Chen, Haibo Cheng and Dongdong Sun

    Citation: Cellular & Molecular Biology Letters 2021 26:19

    Content type: Research Letter

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  32. Mammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mT...

    Authors: Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska and Jacek Jaworski

    Citation: Cellular & Molecular Biology Letters 2021 26:18

    Content type: Research Letter

    Published on:

  33. Most currently recommended therapies for metabolic dysfunction-associated fatty liver disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and compiled the most recent research into po...

    Authors: Jianan Zhao, Yiyang Hu and Jinghua Peng

    Citation: Cellular & Molecular Biology Letters 2021 26:17

    Content type: Review

    Published on:

  34. In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas G...

    Authors: Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan and Hiroaki Konishi

    Citation: Cellular & Molecular Biology Letters 2021 26:16

    Content type: Research Letter

    Published on:

  35. Actin is an essential cellular protein that assembles into microfilaments and regulates numerous processes such as cell migration, maintenance of cell shape, and material transport.

    Authors: Bing Sun, Rongmei Qu, Tingyu Fan, Yuchao Yang, Xin Jiang, Asmat Ullah Khan, Zhitao Zhou, Jingliao Zhang, Kuanhai Wei, Jun Ouyang and Jingxing Dai

    Citation: Cellular & Molecular Biology Letters 2021 26:15

    Content type: Research

    Published on:

  36. The expression signature of deregulated long non-coding RNAs (lncRNAs) and related genetic variants is implicated in every stage of tumorigenesis, progression, and recurrence. This study aimed to explore the a...

    Authors: Shahad W. Kattan, Yahya H. Hobani, Sameerah Shaheen, Sara H. Mokhtar, Mohammad H. Hussein, Eman A. Toraih, Manal S. Fawzy and Hussein Abdelaziz Abdalla

    Citation: Cellular & Molecular Biology Letters 2021 26:14

    Content type: Research

    Published on:

  39. Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell surv...

    Authors: Sylwia Bartoszewska, Jarosław Króliczewski, David K. Crossman, Aneta Pogorzelska, Maciej Bagiński, James F. Collawn and Rafal Bartoszewski

    Citation: Cellular & Molecular Biology Letters 2021 26:11

    Content type: Research

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  40. Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation...

    Authors: Marcin Woźniak, Christian J. Konopka, Agata Płoska, Jamila Hedhli, Anna Siekierzycka, Maciej Banach, Rafal Bartoszewski, Lawrence W. Dobrucki, Leszek Kalinowski and Iwona T. Dobrucki

    Citation: Cellular & Molecular Biology Letters 2021 26:10

    Content type: Research Letter

    Published on:

  41. Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating d...

    Authors: Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang and Lining Wei

    Citation: Cellular & Molecular Biology Letters 2021 26:9

    Content type: Research Letter

    Published on:

  42. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s11658-021-00252-1

    Authors: Yan Hao, Haitao Yuan and Houzhi Yu

    Citation: Cellular & Molecular Biology Letters 2021 26:8

    Content type: Retraction Note

    Published on:

    The original article was published in Cellular & Molecular Biology Letters 2020 25:20

  43. NOTCH signaling has been shown to play a role in the production of interleukin-22 (IL-22) by CD4+ T cells. Multiple T-helper (Th) cell populations secrete IL-22. Th22 (CD4+IL22+IFNγ−IL17A−) cells are a subgroup o...

    Authors: Chong Zeng, Zhongbao Shao, Zibo Wei, Jie Yao, Weidong Wang, Liang Yin, Huixian YangOu and Dan Xiong

    Citation: Cellular & Molecular Biology Letters 2021 26:7

    Content type: Research Letter

    Published on:

  44. ZNF674-AS1, a recently characterized long noncoding RNA, shows prognostic significance in hepatocellular carcinoma and glioma. However, the expression and function of ZNF674-AS1 in non-small cell lung cancer (...

    Authors: Yu Liu, Risheng Huang, Deyao Xie, Xiaoming Lin and Liangcheng Zheng

    Citation: Cellular & Molecular Biology Letters 2021 26:6

    Content type: Research

    Published on:

  45. The synaptic vesicle glycoprotein 2 (SV2) family is essential to the synaptic machinery involved in neurotransmission and vesicle recycling. The isoforms SV2A, SV2B and SV2C are implicated in neurological dise...

    Authors: Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schiöth and Robert Fredriksson

    Citation: Cellular & Molecular Biology Letters 2021 26:5

    Content type: Research Letter

    Published on:

  46. miRNAs are well known to be gene repressors. A newly identified class of miRNAs termed nuclear activating miRNAs (NamiRNAs), transcribed from miRNA loci that exhibit enhancer features, promote gene expression ...

    Authors: Emmanuel Odame, Yuan Chen, Shuailong Zheng, Dinghui Dai, Bismark Kyei, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li and Hongping Zhang

    Citation: Cellular & Molecular Biology Letters 2021 26:4

    Content type: Review

    Published on:

  47. Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppre...

    Authors: Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu and Xuerong Chen

    Citation: Cellular & Molecular Biology Letters 2021 26:3

    Content type: Review

    Published on:

  48. Iron overload, which is common in patients with haematological disorders, is known to have a suppressive effect on haematogenesis. However, the mechanism for this effect is still unclear. The antioxidant curcu...

    Authors: Shujuan Zhou, Lan Sun, Shanhu Qian, Yongyong Ma, Ruye Ma, Yuqing Dong, Yifen Shi, Songfu Jiang, Haige Ye, Zhijian Shen, Shenghui Zhang, Jianping Shen, Kang Yu and Siqian Wang

    Citation: Cellular & Molecular Biology Letters 2021 26:2

    Content type: Research

    Published on:

  49. Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly regulated proteolysis, ubiquitination is now regard...

    Authors: Michal Tracz and Wojciech Bialek

    Citation: Cellular & Molecular Biology Letters 2021 26:1

    Content type: Review Letter

    Published on:

  50. Human cardiac stem cells expressing the W8B2 marker (W8B2+ CSCs) were recently identified and proposed as a new model of multipotent CSCs capable of differentiating into smooth muscle cells, endothelial cells and...

    Authors: Oualid Ayad, Zeina R. Al Sayed, Stéphane Sebille, Christophe Magaud, Charles-Albert Chapotte-Baldacci, Christophe Jayle, Jean-François Faivre, Nathalie Gaborit, Aurélien Chatelier and Patrick Bois

    Citation: Cellular & Molecular Biology Letters 2020 25:50

    Content type: Research Letter

    Published on:

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