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Citation: Cellular & Molecular Biology Letters 2022 27:54
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Raman microspectroscopy fingerprinting of organoid differentiation state
Organoids, which are organs grown in a dish from stem or progenitor cells, model the structure and function of organs and can be used to define molecular events during organ formation, model human disease, ass...
Citation: Cellular & Molecular Biology Letters 2022 27:53 -
The role of epigenetic modifications in drug resistance and treatment of breast cancer
Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic predisposition is the most important factor giving rise to this malignancy. The most not...
Citation: Cellular & Molecular Biology Letters 2022 27:52 -
WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
Diabetic nephropathy (DN) is prevalent in patients with diabetes. N6-methyladenosine (m6A) methylation has been found to cause modification of nucleotide-binding oligomerization domain, leucine-rich repeat, and p...
Citation: Cellular & Molecular Biology Letters 2022 27:51 -
SARS-CoV-2: phenotype, genotype, and characterization of different variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), a major international public health concern. Because of very similar amino acid sequences of th...
Citation: Cellular & Molecular Biology Letters 2022 27:50 -
CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and archaea. Various studies have shown that it is possible to target a wide range of human genes and treat some human diseases, includ...
Citation: Cellular & Molecular Biology Letters 2022 27:49 -
Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is urgent to find novel therapy strategies to overcome this feature. Metformin has been confirmed to suppress invasion...
Citation: Cellular & Molecular Biology Letters 2022 27:48 -
Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it has been discovered that tRNA-derived small RNAs (tsRNAs), a new type of noncoding RNAs,...
Citation: Cellular & Molecular Biology Letters 2022 27:47 -
Reversely immortalized mouse salivary gland cells presented a promising metabolic and fibrotic response upon BMP9/Gdf2 stimulation
The submandibular gland (SMG) and the sublingual gland (SLG) are two of the three major salivary glands in mammals. In mice, they are adjacent to each other and open into the oral cavity, producing saliva to l...
Citation: Cellular & Molecular Biology Letters 2022 27:46 -
Alpha-smooth muscle actin-positive cancer-associated fibroblasts secreting osteopontin promote growth of luminal breast cancer
Cancer-associated fibroblasts (CAFs) have been shown to support tumor development in a variety of cancers. Different markers were applied to classify CAFs in order to elucidate their impact on tumor progressio...
Citation: Cellular & Molecular Biology Letters 2022 27:45 -
Effect of chronic intermittent hypoxia-induced HIF-1α/ATAD2 expression on lung cancer stemness
Obstructive sleep apnea is associated with increased lung cancer incidence and mortality. Cancer stem cells (CSCs) are characterized by their self-renewing ability, which contributes to metastasis, recurrence,...
Citation: Cellular & Molecular Biology Letters 2022 27:44 -
Molecular mechanism of lncRNA SNHG12 in immune escape of non-small cell lung cancer through the HuR/PD-L1/USP8 axis
The pivotal role of long noncoding RNAs (lncRNAs) in cancer immune responses has been well established. This study was conducted with the aim of exploring the molecular mechanism of lncRNA small nucleolar RNA ...
Citation: Cellular & Molecular Biology Letters 2022 27:43 -
COVID-19 therapies: do we see substantial progress?
The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in...
Citation: Cellular & Molecular Biology Letters 2022 27:42 -
METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner
The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic modifications, N6-methyladenosine (m6A) plays key roles in HCC. The aim of this study ...
Citation: Cellular & Molecular Biology Letters 2022 27:41 -
HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway
In patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human cytomegalovirus (HCMV)-miR-US33-5p was significantly increased in the plasma of pati...
Citation: Cellular & Molecular Biology Letters 2022 27:40 -
Identification and validation of an eight-lncRNA signature that predicts prognosis in patients with esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is correlated with worse clinical prognosis and lacks available targeted therapy. Thus, identification of reliable biomarkers is required for the diagnosis and treatme...
Citation: Cellular & Molecular Biology Letters 2022 27:39 -
An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19)
Designing and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotec...
Citation: Cellular & Molecular Biology Letters 2022 27:38 -
Lectins and lectibodies: potential promising antiviral agents
In nature, lectins are widely dispersed proteins that selectively recognize and bind to carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral diseases have been treated w...
Citation: Cellular & Molecular Biology Letters 2022 27:37 -
RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop
RING finger protein 7 (RNF7) is a highly conserved protein that functions as an E3 ubiquitin ligase. RNF7 overexpression is indicated in multiple human cancers, but its role in renal cell carcinoma (RCC) and t...
Citation: Cellular & Molecular Biology Letters 2022 27:36 -
CRISPR/Cas9 application in cancer therapy: a pioneering genome editing tool
The progress of genetic engineering in the 1970s brought about a paradigm shift in genome editing technology. The clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/C...
Citation: Cellular & Molecular Biology Letters 2022 27:35 -
Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy
Vital organ injury is one of the leading causes of global deaths. Accumulating studies have demonstrated that dexmedetomidine (DEX) has an outstanding protective effect on multiple organs for its antiinflammat...
Citation: Cellular & Molecular Biology Letters 2022 27:34 -
Anti-cancer peptide-based therapeutic strategies in solid tumors
Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to d...
Citation: Cellular & Molecular Biology Letters 2022 27:33 -
Tight association of autophagy and cell cycle in leukemia cells
Autophagy plays an essential role in maintaining cellular homeostasis and in the response to cellular stress. Autophagy is also involved in cell cycle progression, yet the relationship between these processes ...
Citation: Cellular & Molecular Biology Letters 2022 27:32 -
CircRbms1 knockdown alleviates hypoxia-induced cardiomyocyte injury via regulating the miR-742-3p/FOXO1 axis
Circular RNA (circRNA) has been shown to play an important role in a variety of cardiovascular diseases, including myocardial infarction (MI). However, the role of circRbms1 in MI progression remains unclear.
Citation: Cellular & Molecular Biology Letters 2022 27:31 -
SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy
Diabetic nephropathy (DN) is regarded as the main vascular complication of diabetes mellitus, directly affecting the outcome of diabetic patients. Inflammatory factors were reported to participate in the progr...
Citation: Cellular & Molecular Biology Letters 2022 27:30 -
Obacunone alleviates ferroptosis during lipopolysaccharide-induced acute lung injury by upregulating Nrf2-dependent antioxidant responses
Acute lung injury (ALI) has received considerable attention in the field of intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in citrus fruits, is a natural bioactive ...
Citation: Cellular & Molecular Biology Letters 2022 27:29 -
Parecoxib inhibits esophageal squamous cell carcinoma progression via the PDK1–AKT pathway
Parecoxib plays an important role in inhibition of human cancer. However, the effect of parecoxib on esophageal squamous cell carcinoma (ESCC) is still not well known. The purpose of this study was to investig...
Citation: Cellular & Molecular Biology Letters 2022 27:28 -
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages
After spinal cord injury (SCI), dysregulated or nonresolving inflammatory processes can severely disturb neuronal homeostasis and drive neurodegeneration. Although mesenchymal stromal cell (MSC)-based therapie...
Citation: Cellular & Molecular Biology Letters 2022 27:27 -
ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1
N6-methyladenosine (m6A) is the most common and abundant internal modification of RNA. Its critical functions in multiple physiological and pathological processes have been reported. However, the role of m6A in s...
Citation: Cellular & Molecular Biology Letters 2022 27:26 -
MiR-5195-3p functions as a tumor suppressor in prostate cancer via targeting CCNL1
Accumulating evidence indicates that miR-5195-3p exerts tumor-suppressive roles in several tumors. However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been ...
Citation: Cellular & Molecular Biology Letters 2022 27:25 -
TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
Transmembrane protein 43 (TMEM43), a member of the transmembrane protein subfamily, plays a critical role in the initiation and development of cancers. However, little is known concerning the biological functi...
Citation: Cellular & Molecular Biology Letters 2022 27:24 -
ROR2 increases the chemoresistance of melanoma by regulating p53 and Bcl2-family proteins via ERK hyperactivation
ROR2 is a tyrosine-kinase receptor whose expression is dysregulated in many human diseases. In cancer, ROR2 stimulates proliferation, survival, migration, and metastasis, and is associated with more aggressive...
Citation: Cellular & Molecular Biology Letters 2022 27:23 -
miR-152-3p impedes the malignant phenotypes of hepatocellular carcinoma by repressing roundabout guidance receptor 1
miR-152-3p functions as a tumour suppressor in the progression of hepatic tumorigenesis. Herein, we further discussed the prognostic significance and immune infiltration of miR-152-3p and its potential gene ta...
Citation: Cellular & Molecular Biology Letters 2022 27:22 -
Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis
Despite great advances, therapeutic approaches of osteosarcoma, the most prevalent class of preliminary pediatric bone tumors, as well as bone-related malignancies, continue to demonstrate insufficient adequac...
Citation: Cellular & Molecular Biology Letters 2022 27:21 -
Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization
EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR mono...
Citation: Cellular & Molecular Biology Letters 2022 27:20 -
Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism
Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins. We demonstrate that PADI2 induces T cell activation and investigate how PADI2 promo...
Citation: Cellular & Molecular Biology Letters 2022 27:19 -
Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma
ΔNp63 overexpression is a common event in squamous cell carcinoma (SCC) that contributes to tumorigenesis, making ΔNp63 a potential target for therapy.
Citation: Cellular & Molecular Biology Letters 2022 27:18 -
Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis
Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms are not well characterized.
Citation: Cellular & Molecular Biology Letters 2022 27:17 -
Exploring neuronal mechanisms involved in the scratching behavior of a mouse model of allergic contact dermatitis by transcriptomics
Allergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin inflammation and a mixed itch and pain sensation. The itch and pain dr...
Citation: Cellular & Molecular Biology Letters 2022 27:16 -
The lncRNA DANCR promotes development of atherosclerosis by regulating the miR-214-5p/COX20 signaling pathway
Although long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) has been reported to be involved in atherosclerosis (AS) development, its specific mechanism remains unclear.
Citation: Cellular & Molecular Biology Letters 2022 27:15 -
MicroRNA let-7 and viral infections: focus on mechanisms of action
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense mechanisms. In particular, miRNA let-7 functions as an ...
Citation: Cellular & Molecular Biology Letters 2022 27:14 -
SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells
In recent years, morbidity and mortality of prostate cancer (PCa) have increased dramatically, while mechanistic understanding of its onset and progression remains unmet. LncRNA SNHG3 has been proved to stimul...
Citation: Cellular & Molecular Biology Letters 2022 27:13 -
ERp57/PDIA3: new insight
The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucle...
Citation: Cellular & Molecular Biology Letters 2022 27:12 -
Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells
A comprehensive understanding of the molecular mechanisms of adipogenesis is a critically important strategy for identifying new targets for obesity intervention.
Citation: Cellular & Molecular Biology Letters 2022 27:11 -
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronaviru...
Citation: Cellular & Molecular Biology Letters 2022 27:10 -
Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review
Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survi...
Citation: Cellular & Molecular Biology Letters 2022 27:9 -
Construction and investigation of β3GNT2-associated regulatory network in esophageal carcinoma
Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, a polylactosamine synthase, is an important member of the glycosyltransferase family. However, the biological ...
Citation: Cellular & Molecular Biology Letters 2022 27:8 -
The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Canonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signal...
Citation: Cellular & Molecular Biology Letters 2022 27:7 -
The probable role and therapeutic potential of the PI3K/AKT signaling pathway in SARS-CoV-2 induced coagulopathy
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate. The majority of deaths in this disease are caused...
Citation: Cellular & Molecular Biology Letters 2022 27:6 -
LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis
Osteosarcoma (OS) is a common primary bone malignancy. Long noncoding RNA HCG18 is known to play an important role in a variety of cancers. However, its role in OS and relevant molecular mechanisms are unclear.
Citation: Cellular & Molecular Biology Letters 2022 27:5
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