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  1. The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angio...

    Authors: Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn and Rafal Bartoszewski
    Citation: Cellular & Molecular Biology Letters 2022 27:109
    Content type: Research Published on:

  2. Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognizes double-stranded DNA. AIM2 exhibits limited expression under physiological conditions ...

    Authors: Jianan Zhao, Shicheng Guo, Steven J. Schrodi and Dongyi He
    Citation: Cellular & Molecular Biology Letters 2022 27:108
    Content type: Review Letter Published on:

  3. Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, and the incidence of OSCC is increasing. As the mortality of OSCC keeps increasing, it is crucial to clarify its pathogenesis and develop n...

    Authors: Xinyu Zhang, Yong Han, Shuli Liu, Bing Guo, Shengming Xu, Yue He and Liu Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:107
    Content type: Research Published on:

  4. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. CircFUT8 has been shown to be upregulated in cancers, but its function in HCC remains unclear. Tumor-associated macrophages (TAMs) are on...

    Authors: Liyan Wang, Xiaoyuan Yi, Xuhua Xiao, Qinghua Zheng, Lei Ma and Bin Li
    Citation: Cellular & Molecular Biology Letters 2022 27:106
    Content type: Research Published on:

  5. Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits ...

    Authors: Dehai Wu, Congyi Zhang, Guanqun Liao, Kaiming Leng, Bowen Dong, Yang Yu, Huilin Tai, Lining Huang, Feng Luo, Bin Zhang, Tiexiang Zhan, Qiuhui Hu and Sheng Tai
    Citation: Cellular & Molecular Biology Letters 2022 27:105
    Content type: Research Published on:

  6. Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemia in brothers of Polish origin that are associated with a very rare mutation. Heterozygous de...

    Authors: Dżamila M. Bogusławska, Michał Skulski, Rafał Bartoszewski, Beata Machnicka, Elżbieta Heger, Kazimierz Kuliczkowski and Aleksander F. Sikorski
    Citation: Cellular & Molecular Biology Letters 2022 27:104
    Content type: Research Published on:

  7. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the ro...

    Authors: Tahseen S. Sayed, Zaid H. Maayah, Heba A. Zeidan, Abdelali Agouni and Hesham M. Korashy
    Citation: Cellular & Molecular Biology Letters 2022 27:103
    Content type: Review Published on:

  8. The innate immune system is the body’s first line of defense against pathogens and involves antibody and complement system-mediated antigen removal. Immune-response-related complement molecules have been ident...

    Authors: Jiali Lu, Jinsong Duan, Yinglun Han, Meng Gou, Jun Li, Qingwei Li and Yue Pang
    Citation: Cellular & Molecular Biology Letters 2022 27:102
    Content type: Research Letter Published on:

  9. RNA N6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulates spermatogenesis and androgen synthesis in an m6A-dependent manner. However, it is uncle...

    Authors: Zhonglin Cai, Yao Zhang, Lin Yang, Chunhui Ma, Yi Fei, Jing Ding, Wei Song, Wei-Min Tong, Yamei Niu and Hongjun Li
    Citation: Cellular & Molecular Biology Letters 2022 27:101
    Content type: Research Letter Published on:

  10. Metformin is an inhibitor of oxidative phosphorylation that displays an array of anticancer activities. The interference of metformin with the activity of multi-drug resistance systems in cancer cells has been...

    Authors: Jessica Catapano, Marcin Luty, Tomasz Wróbel, Maciej Pudełek, Katarzyna Piwowarczyk, Sylwia Kędracka-Krok, Maciej Siedlar, Zbigniew Madeja and Jarosław Czyż
    Citation: Cellular & Molecular Biology Letters 2022 27:100
    Content type: Research Published on:

  11. tRNA-derived fragments (tRFs) are newly discovered noncoding RNAs and regulate tumor progression via diverse molecular mechanisms. However, the expression and biofunction of tRFs in gallbladder cancer (GBC) ha...

    Authors: Lu Zou, Yang Yang, Biyu Zhou, Weijian Li, Ke Liu, Guoqiang Li, Huijie Miao, Xiaoling Song, Jiahua Yang, Yajun Geng, Maolan Li, Runfa Bao and Yingbin Liu
    Citation: Cellular & Molecular Biology Letters 2022 27:99
    Content type: Research Published on:

  12. Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be invol...

    Authors: Gaiping Wang, Anqi Chen, Yu Wu, Danlin Wang, Cuifang Chang and Guoying Yu
    Citation: Cellular & Molecular Biology Letters 2022 27:98
    Content type: Review Letter Published on:

  13. Endothelial cells (ECs) play an important role in angiogenesis and vascular reconstruction in the pathophysiology of ischemic stroke. Previous investigations have provided a profound cerebral vascular atlas un...

    Authors: Zhuohui Chen, Xiang Wang, Haiyue Wu, Yishu Fan, Zhouyi Yan, Chenxiao Lu, Hongfei Ouyang, Shiyu Zhang and Mengqi Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:97
    Content type: Research Published on:

  15. Cardiomyocyte injury is a common complication during cardiac surgery with cardiopulmonary bypass (CPB). Studies have shown that circulating small extracellular vesicles (sEVs) are involved in the pathological ...

    Authors: Ting Wu, Guoning Shi, Zhenhua Ji, Shu Wang, Lizhu Geng and Zhigang Guo
    Citation: Cellular & Molecular Biology Letters 2022 27:95
    Content type: Research Letter Published on:

  17. EVA1A (Eva-1 homolog A), a novel protein involved in autophagy and apoptosis, functions as a tumor suppressor in some human primary cancers, including hepatocellular carcinoma (HCC). While it is consistently d...

    Authors: Qian Xu, Zhaozhong Liao, Zunshuang Gong, Xiaokun Liu, Yuling Yang, Zhe Wang, Weiyan Yang, Lin Hou, Jiejie Yang, Junying Song, Wenjing Liu, Bin Wang, Junnan Hua, Mingyi Pu and Ning Li
    Citation: Cellular & Molecular Biology Letters 2022 27:93
    Content type: Research Published on:

  18. Hepatocellular carcinoma (HCC) is among the most common and malignant cancers with no effective therapeutic approaches. Echinacoside (ECH), a phenylethanoid glycoside isolated from Chinese herbal medicine, Cistan...

    Authors: Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye and Wei Xia
    Citation: Cellular & Molecular Biology Letters 2022 27:92
    Content type: Research Published on:

  19. Long non-coding RNAs (lncRNAs) are critical regulators in lung adenocarcinoma (LUAD). M2-type tumor-associated macrophages (TAMs) also play oncogenic roles in LUAD. However, the involvement of lncRNAs in TAM a...

    Authors: Yue Li, Chen Chen, Hai-lin Liu, Zhen-fa Zhang and Chang-li Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:91
    Content type: Research Published on:

  20. E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic co...

    Authors: Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Long Sun, Fengjiao Zhu, Chengfu Xu and Chaoju Gong
    Citation: Cellular & Molecular Biology Letters 2022 27:90
    Content type: Research Published on:

  21. Numerous studies have revealed that long noncoding RNAs (lncRNAs) are closely related to the development of many diseases and carcinogenesis. However, their specific biological function and molecular mechanism...

    Authors: Lihua Ren, Xin Fang, Sachin Mulmi Shrestha, Qinghua Ji, Hui Ye, Yan Liang, Yang Liu, Yadong Feng, Jingwu Dong and Ruihua Shi
    Citation: Cellular & Molecular Biology Letters 2022 27:89
    Content type: Research Published on:

  22. Current studies show that exosomal miRNAs become an important factor in cancer metastasis. Among the many miRNA studies, miR-7-5p has not been thoroughly investigated in breast cancer metastasis.

    Authors: Zhaoyi Liang, Lu Liu, Ruixia Gao, Chengchuan Che and Ge Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:88
    Content type: Research Letter Published on:

  23. Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with invasive and metastatic characteristics and poor prognosis. Intracellular protein homeostasis is associated with invasion and metastasis of pan...

    Authors: Peng Liu, Fuqiang Zu, Hui Chen, Xiaoli Yin and Xiaodong Tan
    Citation: Cellular & Molecular Biology Letters 2022 27:87
    Content type: Research Published on:

  24. Research on aging is growing as the elderly make up a greater share of the population, focusing on reversing and inhibiting the aging process. The exhaustion and senescence of stem cells are the fundamental dr...

    Authors: Wei V. Zheng, Wang Xu, Yaqin Li, Jie Qin, Tao Zhou, Dezhi Li, Yanwei Xu, Xianyi Cheng, Yu Xiong and Zaizhong Chen
    Citation: Cellular & Molecular Biology Letters 2022 27:86
    Content type: Research Published on:

  25. Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) ...

    Authors: Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo and Guokun Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:85
    Content type: Research Published on:

  26. Long noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional regulation and to gene promoters in gene expression regulation,...

    Authors: Ruiming Li, Xia Wang, Chunming Zhu and Kefeng Wang
    Citation: Cellular & Molecular Biology Letters 2022 27:84
    Content type: Review Published on:

  27. Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migrat...

    Authors: Abdulwahab Teflischi Gharavi, Niloofar Asadi Hanjani, Elaheh Movahed and Mohammad Doroudian
    Citation: Cellular & Molecular Biology Letters 2022 27:83
    Content type: Review Letter Published on:

  28. Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses. The methoxy flavonoid c...

    Authors: Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li and Beixian Zhou
    Citation: Cellular & Molecular Biology Letters 2022 27:82
    Content type: Research Published on:

  29. CDGSH iron sulfur domain 2 (CISD2) is an iron–sulfur protein with a [2Fe–2S] cluster, which is critical for cell proliferation and iron homeostasis. It has been demonstrated that aberrant expression of CISD2 i...

    Authors: Yanchun Li, Bing Xu, Xueying Ren, Luyang Wang, Yaqing Xu, Yefeng Zhao, Chen Yang, Chen Yuan, Huanjuan Li, Xiangmin Tong, Ying Wang and Jing Du
    Citation: Cellular & Molecular Biology Letters 2022 27:81
    Content type: Research Letter Published on:

  30. Extensive inflammation of endothelial cells (ECs) facilitates atherosclerotic lesion formation. Circular RNA (circRNA) participates in atherosclerosis (AS)-related inflammation responses; however, whether and ...

    Authors: Min Zhang, Yiqian Zhu, Jie Zhu, Yi Xie, Ruihao Wu, JiaYin Zhong, Zhaohui Qiu and Li Jiang
    Citation: Cellular & Molecular Biology Letters 2022 27:80
    Content type: Research Published on:

  31. MicroRNAs (miRNAs) play crucial roles in the development of hepatocellular carcinoma (HCC). Hsa-microRNA-27b-3p (hsa-miR-27b) is involved in the formation and progression of various cancers, but its role and clin...

    Authors: Jingyuan Wen, Zhao Huang, Yi Wei, Lin Xue, Yufei Wang, Jingyu Liao, Junnan Liang, Xiaoping Chen, Liang Chu and Bixiang Zhang
    Citation: Cellular & Molecular Biology Letters 2022 27:79
    Content type: Research Published on:

  33. Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as ...

    Authors: Irene Lee-Rivera, Edith López and Ana María López-Colomé
    Citation: Cellular & Molecular Biology Letters 2022 27:77
    Content type: Review Letter Published on:

  34. Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic stat...

    Authors: Jie-pin Li, Yuan-jie Liu, Shu-hong Zeng, Hai-jian Gao, Yu-gen Chen and Xi Zou
    Citation: Cellular & Molecular Biology Letters 2022 27:76
    Content type: Research Published on:

  35. Ulcerative colitis-associated colorectal cancer (UC-CRC) is an important complication of ulcerative colitis. Pou3f1 (POU class 3 homeobox 1) is a critical regulator for developmental events and cellular biolog...

    Authors: Yan Lin, Dongxu Wang, Hong Zhao, Dongyue Li, Xinning Li and Lianjie Lin
    Citation: Cellular & Molecular Biology Letters 2022 27:75
    Content type: Research Published on:

  36. Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered particles are naturally released into...

    Authors: Mohsen Karami Fath, Jalil Azami, Niloofar Jaafari, Mahsa Akbari Oryani, Nafiseh Jafari, Alireza Karim poor, Ali Azargoonjahromi, Mohsen Nabi-Afjadi, Zahra Payandeh, Hamidreza Zalpoor and Dariush Shanehbandi
    Citation: Cellular & Molecular Biology Letters 2022 27:74
    Content type: Review Published on:

  37. Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regulation of circadian rhythms, which is important for optimal human health. Also, melatonin...

    Authors: Amirhossein Davoodvandi, Banafsheh Nikfar, Russel J. Reiter and Zatollah Asemi
    Citation: Cellular & Molecular Biology Letters 2022 27:73
    Content type: Review Letter Published on:

  38. Osteoporotic fractures lead to increased disability and mortality in the elderly population. With the rapid increase in the aging population around the globe, more effective treatments for osteoporosis and ost...

    Authors: Bo Liang, George Burley, Shu Lin and Yan-Chuan Shi
    Citation: Cellular & Molecular Biology Letters 2022 27:72
    Content type: Review Letter Published on:

  39. N-Acetylgalactosaminyltransferases (GALNTs), the enzymes that initiate mucin-type O-glycosylation, are closely associated with tumor occurrence and progression. However, a comprehensive analysis of GALNTs in non-...

    Authors: Qing Hu, Tian Tian, Yahui Leng, Yuanhui Tang, Shuang Chen, Yueyao Lv, Jingyin Liang, Yanni Liu, Tianhui Liu, Li Shen and Xiaoxia Dong
    Citation: Cellular & Molecular Biology Letters 2022 27:71
    Content type: Research Published on:

  41. Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tiss...

    Authors: Mahmoud Al-Azab, Mohammed Safi, Elina Idiiatullina, Fadhl Al-Shaebi and Mohamed Y. Zaky
    Citation: Cellular & Molecular Biology Letters 2022 27:69
    Content type: Review Published on:

  42. Authors: Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu and Zhuo Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:68
    Content type: Correction Published on:

    The original article was published in Cellular & Molecular Biology Letters 2022 27:61

  44. Sestrin2 (SESN2), a stress-inducible protein, has been reported to protect against denervated muscle atrophy through unfolded protein response and mitophagy, while its role in myofiber type transition remains unk...

    Authors: Xiaofan Yang, Pingping Xue, Zhenyu Liu, Wenqing Li, Chuyan Li and Zhenbing Chen
    Citation: Cellular & Molecular Biology Letters 2022 27:66
    Content type: Research Published on:

  45. Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels ...

    Authors: Alireza Mafi, Atefe Rahmati, Zahra Babaei Aghdam, Raziyeh Salami, Marziyeh Salami, Omid Vakili and Esmat Aghadavod
    Citation: Cellular & Molecular Biology Letters 2022 27:65
    Content type: Review Published on:

  46. Progranulin (PGRN) is an autocrine growth factor that regulates cell proliferation, migration, wound healing, and tissue repair in mammals. Lamprey is the most primitive of the extant vertebrates and is regard...

    Authors: Ruixiang Sun, Dong Wang, Yuxuan Song, Qingwei Li, Peng Su and Yue Pang
    Citation: Cellular & Molecular Biology Letters 2022 27:64
    Content type: Research Letter Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2022 27:96

  47. The pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Understanding the entry mechanism of this virus into host cells is essential for effective ...

    Authors: Fahimeh Zamani Rarani, Mohammad Zamani Rarani, Michael R. Hamblin, Bahman Rashidi, Seyed Mohammad Reza Hashemian and Hamed Mirzaei
    Citation: Cellular & Molecular Biology Letters 2022 27:63
    Content type: Review Published on:

  48. Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment with artemisinin (AT) d...

    Authors: Jin Li, Mengqing Jiang, Zhentang Yu, Chenwei Xiong, Jieen Pan, Zhenhai Cai, Nanwei Xu, Xindie Zhou, Yong Huang and Zhicheng Yang
    Citation: Cellular & Molecular Biology Letters 2022 27:62
    Content type: Research Published on:

  49. Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its efficacy. Borneol may promote drug absorption; however, synergism betwee...

    Authors: Jinxiu Li, Jianmei Yuan, Yong Li, Jian Wang, Daoyin Gong, Qian Xie, Rong Ma, Jiajun Wang, Mihong Ren, Danni Lu and Zhuo Xu
    Citation: Cellular & Molecular Biology Letters 2022 27:61
    Content type: Research Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2022 27:68

  50. The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immunological processes, including cell growth, proliferation, differentiation, apoptosis, and inflammat...

    Authors: Hamidreza Zalpoor, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Chanour Tavakol, Faranak Farahighasreaboonasr, Farid Pakizeh, Vahid Ghobadi Dana and Farhad Seif
    Citation: Cellular & Molecular Biology Letters 2022 27:60
    Content type: Review Letter Published on:

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