Martin NA, Falder S. A review of the evidence for threshold of burn injury. Burns. 2017;43(8):1624–39.
Akelma H, Karahan ZA. Rare chemical burns: review of the literature. Int Wound J. 2019;16(6):1330–8.
Coruh A. High voltage electric burn repair of the forehead by reverse flow temporalis muscle flap. J Burn Care Res. 2019;40(3):373–6.
Greenhalgh DG. Management of burns. N Engl J Med. 2019;380(24):2349–59.
Nguyen JQ, Marks HL, Everett T, et al. Early visualization of skin burn severity using a topically applied dye-loaded liquid bandage. Sci Rep. 2020;10(1):9314.
Ye H, De S. Thermal injury of skin and subcutaneous tissues: a review of experimental approaches and numerical models. Burns. 2017;43(5):909–32.
Klein GL. Disruption of bone and skeletal muscle in severe burns. Bone Res. 2015;3:15002.
Rech MA, Mosier MJ, McConkey K, et al. Outcomes in burn-injured patients who develop sepsis. J Burn Care Res. 2019;40(3):269–73.
Forbinake NA, Ohandza CS, Fai KN, et al. Mortality analysis of burns in a developing country: a CAMEROONIAN experience. BMC Public Health. 2020;20(1):1269.
Mariano F, Hollo’ Z, Depetris N, et al. Coupled-plasma filtration and adsorption for severe burn patients with septic shock and acute kidney injury treated with renal replacement therapy. Burns. 2020;46(1):190–8.
Roshangar L, Soleimani Rad J, Kheirjou R, et al. Skin burns: review of molecular mechanisms and therapeutic approaches. Wounds. 2019;31(12):308–15.
Jeschke MG, van Baar ME, Choudhry MA, et al. Burn injury. Nat Rev Dis Primers. 2020;6(1):11.
Oryan A, Alemzadeh E, Moshiri A. Burn wound healing: present concepts, treatment strategies and future directions. J Wound Care. 2017;26(1):5–19.
Hall C, Hardin C, Corkins CJ, et al. Pathophysiologic mechanisms and current treatments for cutaneous sequelae of burn wounds. Compr Physiol. 2017;8(1):371–405.
Wen JJ, Cummins CB, Szczesny B, et al. Cardiac dysfunction after burn injury: role of the AMPK-SIRT1-PGC1α-NFE2L2-ARE pathway. J Am Coll Surg. 2020;230(4):562–71.
Randolph AC, Fukuda S, Ihara K, et al. Blood-brain barrier dysfunction after smoke inhalation injury, with and without skin burn. Shock. 2019;51(5):634–49.
Dey D, Wheatley BM, Cholok D, et al. The traumatic bone: trauma-induced heterotopic ossification. Transl Res. 2017;186:95–111.
Ware AD, Brewer N, Meyers C, et al. Differential vascularity in genetic and nonhereditary heterotopic ossification. Int J Surg Pathol. 2019;27(8):859–67.
Gugala Z, Olmsted-Davis EA, Xiong Y, et al. Trauma-induced heterotopic ossification regulates the blood-nerve barrier. Front Neurol. 2018;9:408.
Herman ZJ, Edelman DG, Ilyas AM. Heterotopic ossification after elbow fractures. Orthopedics. 2021;44(1):10–6.
Levi B, Jayakumar P, Giladi A, et al. Risk factors for the development of heterotopic ossification in seriously burned adults: a National Institute on Disability, Independent Living and Rehabilitation Research burn model system database analysis. J Trauma Acute Care Surg. 2015;79(5):870–6.
Schneider JC, Simko LC, Goldstein R, et al. Predicting heterotopic ossification early after burn injuries: a risk scoring system. Ann Surg. 2017;266(1):179–84.
Thefenne L, de Brier G, Leclerc T, et al. Two new risk factors for heterotopic ossification development after severe burns. PLoS ONE. 2017;12(8):e0182303.
Orchard GR, Paratz JD, Blot S, et al. Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification–a retrospective analysis. J Burn Care Res. 2015;36(4):465–70.
Klein MB, Logsetty S, Costa B, et al. Extended time to wound closure is associated with increased risk of heterotopic ossification of the elbow. J Burn Care Res. 2007;28(3):447–50.
Foster N, Kornhaber R, McGarry S, et al. Heterotopic ossification in adults following a burn: a phenomenological analysis. Burns. 2017;43(6):1250–62.
Yelvington ML, Godleski M, Lee AF, et al. A comparison of contracture severity at acute discharge in patients with and without heterotopic ossification: a burn model system national database study. J Burn Care Res. 2019;40(3):349–54.
Mohammadi AA, Foroutan A, Karvar M, et al. Recurrent nonhealing wound in old burn scar may be due to heterotopic ossification. Burns. 2017;43(7):1599–601.
Łęgosz P, Otworowski M, Sibilska A, et al. Heterotopic ossification: a challenging complication of total hip arthroplasty: risk factors, diagnosis, prophylaxis, and treatment. Biomed Res Int. 2019;2019:3860142.
Mourad WF, Packianathan S, Ma JK, et al. Computerized tomography-based radiotherapy improves heterotopic ossification outcomes. Bone. 2013;57(1):132–6.
Zagarella A, Impellizzeri E, Maiolino R, et al. Pelvic heterotopic ossification: when CT comes to the aid of MR imaging. Insights Imaging. 2013;4(5):595–603.
Seraj SM, Al-Zaghal A, Østergaard B, et al. Identification of heterotopic ossification using 18F-NaF PET/CT. Clin Nucl Med. 2019;44(4):319–20.
Chalmers J, Gray DH, Rush J. Observations on the induction of bone in soft tissues. J Bone Joint Surg Br. 1975;57(1):36–45.
Yin N, Zhu L, Ding L, et al. MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells. Cell Mol Biol Lett. 2019;24:51.
Nelson ER, Wong VW, Krebsbach PH, et al. Heterotopic ossification following burn injury: the role of stem cells. J Burn Care Res. 2012;33(4):463–70.
Zhang WH, Li XL, Guo Y, et al. Proliferation and osteogenic activity of fibroblasts induced with fibronectin. Braz J Med Biol Res. 2017;50(10):e6272.
Lees-Shepard JB, Goldhamer DJ. Stem cells and heterotopic ossification: lessons from animal models. Bone. 2018;109:178–86.
Feng H, Xing W, Han Y, et al. Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. J Clin Invest. 2020;130(12):6354–65.
Yu X, Wan Q, Ye X, et al. Cellular hypoxia promotes osteogenic differentiation of mesenchymal stem cells and bone defect healing via STAT3 signaling. Cell Mol Biol Lett. 2019;24:64.
Zhou X, Xu W, Wang Y, et al. LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions. Cell Mol Biol Lett. 2021;26(1):22.
Zhuravleva K, Goertz O, Wölkart G, et al. The tight junction protein cingulin regulates the vascular response to burn injury in a mouse model. Microvasc Res. 2020;132:104067.
Cromer WE, Zawieja SD, Doersch KM, et al. Burn injury-associated MHCII + immune cell accumulation around lymphatic vessels of the mesentery and increased lymphatic endothelial permeability are blocked by doxycycline treatment. Lymphat Res Biol. 2018;16(1):56–64.
Peterson JR, De La Rosa S, Sun H, et al. Burn injury enhances bone formation in heterotopic ossification model. Ann Surg. 2014;259(5):993–8.
Xing D, Liu L, Marti GP, et al. Hypoxia and hypoxia-inducible factor in the burn wound. Wound Repair Regen. 2011;19(2):205–13.
Miyanaga T, Ueda Y, Miyanaga A, et al. Angiogenesis after administration of basic fibroblast growth factor induces proliferation and differentiation of mesenchymal stem cells in elastic perichondrium in an in vivo model: mini review of three sequential republication-abridged reports. Cell Mol Biol Lett. 2018;23:49.
Hwang C, Marini S, Huber AK, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36.
Behr B, Sorkin M, Lehnhardt M, et al. A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model. Tissue Eng Part A. 2012;18(9–10):1079–86.
Behr B, Tang C, Germann G, et al. Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells. 2011;29(2):286–96.
Agarwal S, Loder S, Cholok D, et al. Local and circulating endothelial cells undergo endothelial to mesenchymal transition (EMT) in response to musculoskeletal injury. Sci Rep. 2016;6:32514.
Medici D, Olsen BR. The role of endothelial-mesenchymal transition in heterotopic ossification. J Bone Miner Res. 2012;27(8):1619–22.
Zhang F, Qiu XC, Wang JJ, et al. Burn-related dysregulation of inflammation and immunity in experimental and clinical studies. J Burn Care Res. 2017;38(6):e892-9.
Sorkin M, Huber AK, Hwang C, et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020;11(1):722.
Ranganathan K, Agarwal S, Cholok D, et al. The role of the adaptive immune system in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation. J Surg Res. 2016;206(1):53–61.
Kan C, Yang J, Na D, et al. Inhibition of immune checkpoints prevents injury-induced heterotopic ossification. Bone Res. 2019;7:33.
Yousuf Y, Jeschke MG, Shah A, et al. The response of muscle progenitor cells to cutaneous thermal injury. Stem Cell Res Ther. 2017;8(1):234.
Karlsen A, Soendenbroe C, Malmgaard-Clausen NM, et al. Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men. FASEB J. 2020;34(5):6418–36.
Hashimoto N, Kiyono T, Wada MR, et al. Osteogenic properties of human myogenic progenitor cells. Mech Dev. 2008;125(3–4):257–69.
Wu X, Walters TJ, Rathbone CR. Skeletal muscle satellite cell activation following cutaneous burn in rats. Burns. 2013;39(4):736–44.
Wu X, Rathbone CR. Satellite cell functional alterations following cutaneous burn in rats include an increase in their osteogenic potential. J Surg Res. 2013;184(2):e9–16.
Peterson JR, Eboda ON, Brownley RC, et al. Effects of aging on osteogenic response and heterotopic ossification following burn injury in mice. Stem Cells Dev. 2015;24(2):205–13.
Ranganathan K, Peterson J, Agarwal S, et al. Role of gender in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation. Plast Reconstr Surg. 2015;135(6):1631–41.
Thorpe CR, Ucer Ozgurel S, Simko LC, et al. Investigation into possible association of oxandrolone and heterotopic ossification following burn injury. J Burn Care Res. 2019;40(4):398–405.
Klifto KM, Dellon AL, Hultman CS. Risk factors associated with the progression from acute to chronic neuropathic pain after burn-related injuries. Ann Plast Surg. 2020;84(6S Suppl 5):382–5.
Strong AL, Agarwal S, Cederna PS, et al. Peripheral neuropathy and nerve compression syndromes in burns. Clin Plast Surg. 2017;44(4):793–803.
Choi JE, Di Nardo A. Skin neurogenic inflammation. Semin Immunopathol. 2018;40(3):249–59.
Rogoz K, Andersen HH, Kullander K, et al. Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia. Mol Pharmacol. 2014;85(2):322–34.
Niedermair T, Schirner S, Seebröker R, et al. Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts. Sci Rep. 2018;8(1):9199.
Tuzmen C, Verdelis K, Weiss L, et al. Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon. J Orthop Res. 2018;36(5):1444–55.
Lazard ZW, Olmsted-Davis EA, Salisbury EA, et al. Osteoblasts have a neural origin in heterotopic ossification. Clin Orthop Relat Res. 2015;473(9):2790–806.
Klein GL. The role of calcium in inflammation-associated bone resorption. Biomolecules. 2018;8(3):69.
Muschitz GK, Schwabegger E, Kocijan R, et al. Early and sustained changes in bone metabolism after severe burn injury. J Clin Endocrinol Metab. 2016;101(4):1506–15.
Rada B, Park JJ, Sil P, et al. NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res. 2014;63(10):821–30.
Altman R, Bosch B, Brune K, et al. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859–77.
Pountos I, Giannoudis PV, Jones E, et al. NSAIDS inhibit in vitro MSC chondrogenesis but not osteogenesis: implications for mechanism of bone formation inhibition in man. J Cell Mol Med. 2011;15(3):525–34.
Joice M, Vasileiadis GI, Amanatullah DF. Non-steroidal anti-inflammatory drugs for heterotopic ossification prophylaxis after total hip arthroplasty: a systematic review and meta-analysis. Bone Joint J. 2018;100-B(7):915–22.
Migliorini F, Trivellas A, Eschweiler J, et al. NSAIDs for prophylaxis for heterotopic ossification after total hip arthroplasty: a bayesian network meta-analysis. Calcif Tissue Int. 2021;108(2):196–206.
Lisowska B, Kosson D, Domaracka K. Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair. Drug Des Dev Ther. 2018;12:1809–14.
Wheatley BM, Nappo KE, Christensen DL, et al. Effect of NSAIDs on bone healing rates: a meta–analysis. J Am Acad Orthop Surg. 2019;27(7):e330-6.
Hu ZH, Chen W, Sun JN, et al. Radiotherapy for the prophylaxis of heterotopic ossification after total hip arthroplasty: a systematic review and meta-analysis of randomized controlled trails. Med Dosim. 2021;46(1):65–73.
Pohl F, Hassel S, Nohe A, et al. Radiation-induced suppression of the Bmp2 signal transduction pathway in the pluripotent mesenchymal cell line C2C12: an in vitro model for prevention of heterotopic ossification by radiotherapy. Radiat Res. 2003;159(3):345–50.
Honore T, Bonan I, Salga M, et al. Effectiveness of radiotherapy to prevent recurrence of heterotopic ossification in patients with spinal cord injury and traumatic head injury: a retrospective case-controlled study. J Rehabil Med. 2020;52(5):jrm00066.
Rosenberg DM, Onderdonk B, Majeed NK, et al. Radiation-induced sarcoma after heterotopic ossification prophylaxis: a case report. JBJS Case Connect. 2019;9(4):e0146.
Chen HC, Yang JY, Chuang SS, et al. Heterotopic ossification in burns: our experience and literature reviews. Burns. 2009;35(6):857–62.
Chen JY, Fu CW, Ho HY, et al. Surgical treatment of postburn heterotopic ossification around the elbow: three case reports. Medicine. 2019;98(6):e14403.
Agarwal S, Loder S, Cholok D, et al. Surgical excision of heterotopic ossification leads to re-emergence of mesenchymal stem cell populations responsible for recurrence. Stem Cells Transl Med. 2017;6(3):799–806.
Maender C, Sahajpal D, Wright TW. Treatment of heterotopic ossification of the elbow following burn injury: recommendations for surgical excision and perioperative prophylaxis using radiation therapy. J Shoulder Elbow Surg. 2010;19(8):1269–75.