Ying Y, Zhu H, Liang Z, Ma X, Li S. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. J Mol Endocrinol. 2015;55:245–62.
Article
CAS
Google Scholar
Li W, Fang Q, Zhong P, Chen L, Wang L, Zhang Y, Wang J, Li X, Wang Y, Wang J, Liang GEGFR. Inhibition blocks palmitic acid-induced inflammation in cardiomyocytes and prevents hyperlipidemia-induced cardiac injury in mice. Sci Rep. 2016;6:24580.
Article
CAS
Google Scholar
Cao L, Qin X, Peterson MR, Haller SE, Wilson KA, Hu N, Lin X, Nair S, Ren J, He G. CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. J Mol Cell Cardiol. 2016;92:185–95.
Article
CAS
Google Scholar
Fang Q, Wang J, Zhang Y, Wang L, Li W, Han J, Huang W, Liang G, Wang Y. Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis. Biochim Biophys Acta. 2018;1864:252–62.
Article
CAS
Google Scholar
Xu L, Brink M. mTOR, cardiomyocytes and inflammation in cardiac hypertrophy. Biochim Biophys Acta. 1863;2016:1894–903.
Google Scholar
Jiao C, Gao F, Ou L, Yu J, Li M, Wei P, Miao F. Tetrahydroxy stilbene glycoside (TSG) antagonizes Abeta-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway. Biomed Pharmacother. 2017;96:222–8.
Article
CAS
Google Scholar
Jiang Z, Wang W, Guo C. Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses. Mol Med Rep. 2017;16:5219–24.
Article
CAS
Google Scholar
Mikula-Pietrasik J, Sosinska P, Murias M, Michalak M, Wierzchowski M, Piechota M, Sikora E, Ksiazek K. Resveratrol Derivative, 3,3′,4,4'-Tetrahydroxy-trans-stilbene, retards senescence of mesothelial cells via Hormetic-like Prooxidative mechanism. J Gerontol A Biol Sci Med Sci. 2015;70:1169–80.
Article
CAS
Google Scholar
Zeglinski MR, Hnatowich M, Jassal DS, Dixon IM. SnoN as a novel negative regulator of TGF-beta/Smad signaling: a target for tailoring organ fibrosis. Am J Physiol Heart Circ Physiol. 2015;308:H75–82.
Article
CAS
Google Scholar
Yang S, Mi X, Chen Y, Feng C, Hou Z, Hui R, Zhang W. MicroRNA-216a induces endothelial senescence and inflammation via Smad3/IkappaBalpha pathway, vol. 22; 2018. p. 2739–49.
Google Scholar
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, Lin X, Feng XH. STAT3 selectively interacts with Smad3 to antagonize TGF-beta signalling. Oncogene. 2016;35:4388–98.
Article
CAS
Google Scholar
Zhou H, Yang HX, Yuan Y, Deng W, Zhang JY, Bian ZY, Zong J, Dai J, Tang QZ. Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGFbeta/Smads and NF-kappaB pathways. J Mol Histol. 2013;44:357–67.
Article
CAS
Google Scholar
Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X, Zhu X. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol. 2012;14:697–706.
Article
CAS
Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 2001;25:402–8.
Article
CAS
Google Scholar
Batumalaie K, Amin MA, Murugan DD, Sattar MZ, Abdullah NA. Withaferin a protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation. Sci Rep. 2016;6:27236.
Article
CAS
Google Scholar
Ohtsu A, Tanaka H, Seno K, Iwata H, Kuwayama T, Shirasuna K. Palmitic acid stimulates interleukin-8 via the TLR4/NF-kappaB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial Cell. Am J Reprod Immunol. 2017;77. https://doi.org/10.1111/aji.12642.
Sadeghi A, Seyyed Ebrahimi SS, Golestani A, Meshkani R. Resveratrol ameliorates palmitate-induced inflammation in skeletal muscle cells by attenuating oxidative stress and JNK/NF-kappaB pathway in a SIRT1-independent mechanism. J Cell Biochem. 2017;118:2654–63.
Article
CAS
Google Scholar
Niu J, Wang K, Kolattukudy PE. Cerium oxide nanoparticles inhibit oxidative stress and nuclear factor-kappaB activation in H9c2 cardiomyocytes exposed to cigarette smoke extract. J Pharmacol Exp Ther. 2011;338:53–61.
Article
CAS
Google Scholar
He Y, Zhou L, Fan Z, Liu S, Fang W. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by Nacetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell Death Dis. 2018;9:568.
Article
Google Scholar
Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY. Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes. 2001;50:2105–13.
Article
CAS
Google Scholar
Li J, Wang B, Zhou G, Yan X, Zhang Y. Tetrahydroxy stilbene glucoside alleviates high glucose-induced MPC5 podocytes injury through suppression of NLRP3 Inflammasome. Am J Med Sci. 2018;355:588–96.
Article
Google Scholar
Luo HB, Yang JS, Shi XQ, Fu XF, Yang QD. Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure. Neurosci Bull. 2009;25:391–6.
Article
Google Scholar
Sun YB, Qu X, Howard V, Dai L, Jiang X, Ren Y, Fu P, Puelles VG, Nikolic-Paterson DJ, Caruana G, Bertram JF, Sleeman MW, Li J. Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance. Kidney Int. 2015;88:286–98.
Article
CAS
Google Scholar
Liang H, Zhong Y, Zhou S, Li QQ. Palmitic acid-induced apoptosis in pancreatic beta-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate. In Vivo. 2011;25:711–8.
CAS
PubMed
Google Scholar
Chen T, Li J, Liu J, Li N, Wang S, Liu H, Zeng M, Zhang Y. Bu P. activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-beta/Smad3 pathway. Am J Physiol Heart Circ Physiol. 2015;308:H424–34.
Article
CAS
Google Scholar
Yang YH, Fang HL, Zhao M, Wei XL, Zhang N, Wang S, Lu Y, Yu XJ, Sun L, He X, Li DL, Liu JJ, Zang WJ. Specific alpha7 nicotinic acetylcholine receptor agonist ameliorates isoproterenol-induced cardiac remodelling in mice through TGF-beta1/Smad3 pathway, vol. 44; 2017. p. 1192–200.
Google Scholar
Zhang F, Dang Y, Li Y, Hao Q, Li R, Qi X. Cardiac contractility modulation attenuate myocardial fibrosis by inhibiting TGF-beta1/Smad3 signaling pathway in a rabbit model of chronic heart failure. Cell Physiol Biochem. 2016;39:294–302.
Article
CAS
Google Scholar
Kong P, Shinde AV, Su Y, Russo I, Chen B, Saxena A, Conway SJ, Graff JM, Frangogiannis NG. Opposing actions of fibroblast and cardiomyocyte Smad3 signaling in the infarcted myocardium. Circulation. 2018;137:707–24.
Article
CAS
Google Scholar
Zhang H, Cui YC, Li K, Yang BQ, Liu XP, Zhang D, Li H, Wu AL, Tang Y. Glutamine protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions through inhibition of the transforming growth factor-beta1-Smad3 pathway. Arch Biochem Biophys. 2016;596:43–50.
Article
CAS
Google Scholar
Liu GX, Li YQ, Huang XR, Wei L, Chen HY, Shi YJ, Heuchel RL, Lan HY. Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NF.kappaB-dependent mechanisms in mice. PLoS One. 2013;8:e53573.
Article
CAS
Google Scholar
Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA. Inflammasome-independent NLRP3 augments TGF-beta signaling in kidney epithelium. J Immunol. 2013;190:1239–49.
Article
CAS
Google Scholar
Wang J, Huang W, Xu R, Nie Y, Cao X, Meng J, Xu X, Hu S, Zheng Z. MicroRNA-24 regulates cardiac fibrosis after myocardial infarction. J Cell Mol Med. 2012;16:2150–60.
Article
CAS
Google Scholar
Jeppesen PL, Christensen GL, Schneider M, Nossent AY, Jensen HB, Andersen DC, Eskildsen T, Gammeltoft S, Hansen JL, Sheikh SP. Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes. Br J Pharmacol. 2011;164:394–404.
Article
CAS
Google Scholar
Cakmak HA, Coskunpinar E, Ikitimur B, Barman HA, Karadag B, Tiryakioglu NO, Kahraman K, Vural VA. The prognostic value of circulating microRNAs in heart failure: preliminary results from a genome-wide expression study. J Cardiovasc Med (Hagerstown). 2015;16:431–7.
Article
CAS
Google Scholar