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Citation: Cellular & Molecular Biology Letters 2016 20:999
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Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair
The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury.
Citation: Cellular & Molecular Biology Letters 2016 21:19 -
BAG2 structure, function and involvement in disease
Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members. Functioning as a co-chaperone, it interacts with the ATPase domain of the heat shock protein...
Citation: Cellular & Molecular Biology Letters 2016 21:18 -
Obituary: remembering professor Arkadiusz Kozubek (1947–2016)
Citation: Cellular & Molecular Biology Letters 2016 21:17 -
Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs
Understanding the cellular pathways that regulate endothelial nitric oxide (eNOS, NOS3) expression and consequently nitric oxide (NO) bioavailability during hypoxia is a necessary aspect in the development of nov...
Citation: Cellular & Molecular Biology Letters 2016 21:16 -
Nuclear and nucleolar activity of linker histone variant H1.0
Histone H1.0 belongs to the class of linker histones (H1), although it is substantially distinct from other histone H1 family members. The differences can be observed in the chromosomal location and organizati...
Citation: Cellular & Molecular Biology Letters 2016 21:15 -
Changes in expression of cartilaginous genes during chondrogenesis of Wharton’s jelly mesenchymal stem cells on three-dimensional biodegradable poly(L-lactide-co-glycolide) scaffolds
In cartilage tissue regeneration, it is important to develop biodegradable scaffolds that provide a structural and logistic template for three-dimensional cultures of chondrocytes. In this study, we evaluated ...
Citation: Cellular & Molecular Biology Letters 2016 21:14 -
Effects of NH4CL application and removal on astrocytes and endothelial cells
Hepatic encephalopathy (HE) is a complex disorder associated with increased ammonia levels in the brain. Although astrocytes are believed to be the principal cells affected in hyperammonemia (HA), endothelial ...
Citation: Cellular & Molecular Biology Letters 2016 21:13 -
Osteoporosis: the current status of mesenchymal stem cell-based therapy
Osteoporosis, or bone loss, is a progressive, systemic skeletal disease that affects millions of people worldwide. Osteoporosis is generally age related, and it is underdiagnosed because it remains asymptomati...
Citation: Cellular & Molecular Biology Letters 2016 21:12 -
In vitro chondrogenesis of Wharton’s jelly mesenchymal stem cells in hyaluronic acid-based hydrogels
In this study, we evaluated the usefulness of two commercially available hyaluronic acid-based hydrogels, HyStem and HyStem-C, for the cultivation of Wharton’s jelly mesenchymal stem cells (WJ-MSCs) and their ...
Citation: Cellular & Molecular Biology Letters 2016 21:11 -
A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL
This study focused on an extract from fermented flour from the Lady Joy variety of the common bean Phaseolus vulgaris. The extract, Lady Joy lysate (Lys LJ), is enriched in antioxidant compounds during the fermen...
Citation: Cellular & Molecular Biology Letters 2016 21:10 -
WNT5A–ROR2 is induced by inflammatory mediators and is involved in the migration of human ovarian cancer cell line SKOV-3
Wnt5A, which is a member of the non-transforming Wnt protein family, is implicated in inflammatory processes. It is also highly expressed by ovarian cancer cells. ROR2, which is a member of the Ror-family of r...
Citation: Cellular & Molecular Biology Letters 2016 21:9 -
Effect of differentiation on microRNA expression in bovine skeletal muscle satellite cells by deep sequencing
The differentiation of skeletal muscle-derived satellite cells (MDSCs) is important in controlling muscle growth, improving livestock muscle quality, and healing of muscle-related disease. MicroRNAs (miRNAs) a...
Citation: Cellular & Molecular Biology Letters 2016 21:8 -
Regulation of phosphorus uptake and utilization: transitioning from current knowledge to practical strategies
Phosphorus is a poorly bioavailable macronutrient that is essential for crop growth and yield. Overuse of phosphorus fertilizers results in low phosphorus use efficiency (PUE), has serious environmental conseq...
Citation: Cellular & Molecular Biology Letters 2016 21:7 -
Natural antisense RNAs as mRNA regulatory elements in bacteria: a review on function and applications
Naturally occurring antisense RNAs are small, diffusible, untranslated transcripts that pair to target RNAs at specific regions of complementarity to control their biological function by regulating gene expres...
Citation: Cellular & Molecular Biology Letters 2016 21:6 -
Nuclear expression of TCF4/TCF7L2 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma
The prognosis for patients with esophageal cancer remains poor. Therefore, the identification of novel target molecules for the treatment of esophageal cancer is necessary. Here, we investigated the clinicopat...
Citation: Cellular & Molecular Biology Letters 2016 21:5 -
Identification of a novel deletion in the MMAA gene in two Iranian siblings with vitamin B12-responsive methylmalonic acidemia
Adenosylcobalamin (vitamin B12) is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this enzyme are a cause of methylmalonic acidemia (MMA). Methylmalonic acidemia, cblA type, is an...
Citation: Cellular & Molecular Biology Letters 2016 21:4 -
The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A
miR-126 is a key regulator of oncogenic processes. It is functionally linked to cellular proliferation, survival and migration. Vascular endothelial growth factor A (VEGF-A), which is regarded as a tumorgenesi...
Citation: Cellular & Molecular Biology Letters 2016 21:3 -
Toll-like receptor 2 and type 2 diabetes
Innate immunity plays a crucial role in the pathogenesis of type 2 diabetes and related complications. Since the toll-like receptors (TLRs) are central to innate immunity, it appears that they are important pa...
Citation: Cellular & Molecular Biology Letters 2016 21:2 -
Cellular and Molecular Biology Letters goes open access with BioMed Central
Citation: Cellular & Molecular Biology Letters 2016 21:1 -
Cyclic phosphatidic acid induces G0/G1 arrest, inhibits Akt phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells
Lysophosphatidic acid (LPA) and its analogs are well-known mitogens for various cell types. Many reports have confirmed that several types of cancer cell produce LPA to promote survival, growth and tumorigenes...
Citation: Cellular & Molecular Biology Letters 2014 :224 -
Identification of drought-induced transcription factors in Sorghum bicolor using GO term semantic similarity
Stress tolerance in plants is a coordinated action of multiple stress response genes that also cross talk with other components of the stress signal transduction pathways. The expression and regulation of stre...
Citation: Cellular & Molecular Biology Letters 2014 :223 -
Evaluation of the potential of alkylresorcinols as superoxide anion scavengers and sox-regulon modulators using nitroblue tetrazolium and bioluminescent cell-based assays
The antioxidant activities of five alkylresorcinol (AR) homologs with alkyl chains of 1, 3, 5 6 and 12 carbon atoms were studied using molecular and cellular assays for superoxide anions ( ...
Citation: Cellular & Molecular Biology Letters 2014 :222 -
FunPred-1: Protein function prediction from a protein interaction network using neighborhood analysis
Proteins are responsible for all biological activities in living organisms. Thanks to genome sequencing projects, large amounts of DNA and protein sequence data are now available, but the biological functions ...
Citation: Cellular & Molecular Biology Letters 2014 19:221 -
The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes
We aim to demonstrate the role of Alk receptors in the response of hydrogel expansion. Chondrocytes from rat knees were cultured onto plastic and hydrogel surfaces. Alk-1 and Alk-5 were overexpressed or silenc...
Citation: Cellular & Molecular Biology Letters 2014 19:220 -
Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression
Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the...
Citation: Cellular & Molecular Biology Letters 2014 19:219 -
The PPARα pathway in Vγ9Vδ2 T cell anergy
Phosphoantigens (PAgs) activate Vγ9Vδ2 T lymphocytes, inducing their potent and rapid response in vitro and in vivo. However, humans and nonhuman primates that receive repeated injections of PAgs progressively...
Citation: Cellular & Molecular Biology Letters 2014 19:218 -
The effect of buffalo CD14 shRNA on the gene expression of TLR4 signal pathway in buffalo monocyte/macrophages
CD14 plays a crucial role in the inflammatory response to lipopolysaccharide (LPS), which interacts with TLR4 and MD-2 to enable cell activation, resulting in inflammation. Upstream inhibition of the inflammat...
Citation: Cellular & Molecular Biology Letters 2014 19:217 -
Gene expression patterns in bone following lipopolysaccharide stimulation
Bone displays suppressed osteogenesis in inflammatory diseases such as sepsis and rheumatoid arthritis. However, the underlying mechanisms have not yet been clearly explained. To identify the gene expression p...
Citation: Cellular & Molecular Biology Letters 2014 19:216 -
Promoted megakaryocytic differentiation of K562 cells through oxidative stress caused by near ultraviolet irradiation
Reactive oxygen species (ROS) have been proven to be important activators for various cellular activities, including cell differentiation. Several reports showed the necessity of ROS during cell differentiatio...
Citation: Cellular & Molecular Biology Letters 2014 19:215 -
Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture
The interstitial cells of Cajal (ICC) drive the slow wave-associated contractions in the small intestine. A commonly used marker for these cells is c-Kit, but another marker named Ano1 was recently described. Thi...
Citation: Cellular & Molecular Biology Letters 2014 19:214 -
Attenuation of enoyl coenzyme A hydratase short chain 1 expression in gastric cancer cells inhibits cell proliferation and migration in vitro
Enoyl coenzyme A hydratase short chain 1 (ECHS1) is an important part of the mitochondrial fatty acid β-oxidation pathway. Altered ECHS1 expression has been implicated in cancer cell proliferation. This study ...
Citation: Cellular & Molecular Biology Letters 2014 19:213 -
Regulation of lncRNA expression
Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. I...
Citation: Cellular & Molecular Biology Letters 2014 19:212 -
In vitro effects of prolonged exposure to quercetin and epigallocatechin gallate of the peripheral blood mononuclear cell membrane
The study aimed to assess biophysical changes that take place in the peripheral blood mononuclear cell (PBMC) membranes when exposed in vitro to 10 μM quercetin or epigallocatechin gallate (EGCG) for 24 and 48...
Citation: Cellular & Molecular Biology Letters 2014 19:211 -
Downregulation of KDR expression induces apoptosis in breast cancer cells
Angiogenesis plays a crucial role in the growth, invasion and metastasis of breast cancer. Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are the key regulators of tumor angiogenesis....
Citation: Cellular & Molecular Biology Letters 2014 19:210 -
The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes
Resveratrol is the most extensively studied stilbene derivative. We previously showed that methylthiostilbenes were more effective inhibitors of CYP1A1 and 1B1 activity than resveratrol. In this study, we inve...
Citation: Cellular & Molecular Biology Letters 2014 19:209 -
Dysregulation of gene expression in ABCC6 knockdown HepG2 cells
ABCC6 protein is an ATP-dependent transporter that is mainly found in the basolateral plasma membrane of hepatocytes. ABCC6 deficiency is the primary cause of several forms of ectopic mineralization syndrome. ...
Citation: Cellular & Molecular Biology Letters 2014 19:208 -
miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells
This paper focuses on the development of renewable sources of isletreplacement tissue for the treatment of type I diabetes mellitus. Placental tissue-derived mesenchymal stem cells (MSCs) are a promising sourc...
Citation: Cellular & Molecular Biology Letters 2014 19:207 -
The lectin-binding pattern of nucleolin and its interaction with endogenous galectin-3
Unlike nuclear nucleolin, surface-expressed and cytoplasmic nucleolin exhibit Tn antigen. Here, we show localization-dependent differences in the glycosylation and proteolysis patterns of nucleolin. Our result...
Citation: Cellular & Molecular Biology Letters 2014 19:206 -
The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach
Protein glycation is initiated by a nucleophilic addition reaction between the free amino group from a protein, lipid or nucleic acid and the carbonyl group of a reducing sugar. This reaction forms a reversibl...
Citation: Cellular & Molecular Biology Letters 2014 19:205 -
The potential role of O-GlcNAc modification in cancer epigenetics
There is no doubt that cancer is not only a genetic disease but that it can also occur due to epigenetic abnormalities. Diet and environmental factors can alter the scope of epigenetic regulation. The results ...
Citation: Cellular & Molecular Biology Letters 2014 19:204 -
Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer
The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents...
Citation: Cellular & Molecular Biology Letters 2014 19:203 -
CD39/NTPDase-1 expression and activity in human umbilical vein endothelial cells are differentially regulated by leaf extracts from Rubus caesius and Rubus idaeus
Many experimental studies have demonstrated the favorable biological activities of plants belonging to the genus Rubus, but little is known of the role of Rubus leaf extracts in the modulation of the surface memb...
Citation: Cellular & Molecular Biology Letters 2014 19:202 -
p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation
The large microtubule-associated/Ca2+-signalling protein p600 (also known as UBR4) is required for hippocampal neuronal survival upon Ca2+ dyshomeostasis induced by glutamate treatment. During this process, p600 ...
Citation: Cellular & Molecular Biology Letters 2014 19:201 -
Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3β
Cannabinoids display various pharmacological activities, including tumor regression, anti-inflammatory and neuroprotective effects. To investigate the molecular mechanisms underlying the pharmacological effect...
Citation: Cellular & Molecular Biology Letters 2014 19:200 -
Expression profiles uncover the relationship between erythropoietin and cell proliferation in rat hepatocytes after a partial hepatectomy
Erythropoietin (EPO) has a beneficial effect on hepatic cell proliferation during liver regeneration. However, the underlying mechanism has not yet been elucidated. To uncover the proliferation response of EPO...
Citation: Cellular & Molecular Biology Letters 2014 19:198 -
Fannin-Lubbock-I [α2β2119(GLY>ASP)], a rare mutation in the beta-globin gene, has been detected for the first time in a Hindu Brahmin family in West Bengal, India
This study aims to describe the hemoglobin Fannin-Lubbock-I, which has a rare mutation substituting the amino acid glycine with aspartic acid at codon 119 of the β-globin chain. A Bengalee Hindu Brahmin family...
Citation: Cellular & Molecular Biology Letters 2014 19:192 -
The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue
We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds — 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic aci...
Citation: Cellular & Molecular Biology Letters 2014 19:193 -
Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy
Radiotherapy and chemotherapeutic agents that damage DNA are the current major non-surgical means of treating cancer. However, many patients develop resistances to chemotherapy drugs in their later lives. The ...
Citation: Cellular & Molecular Biology Letters 2014 19:191 -
Transport of 3-bromopyruvate across the human erythrocyte membrane
3-Bromopyruvic acid (3-BP) is a promising anticancer compound because it is a strong inhibitor of glycolytic enzymes, especially glyceraldehyde 3-phosphate dehydrogenase. The Warburg effect means that malignan...
Citation: Cellular & Molecular Biology Letters 2014 19:189
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